国家: 澳大利亚
语言: 英文
来源: Department of Health (Therapeutic Goods Administration)
papaverine hydrochloride
Pfizer Australia Pty Ltd
Papaverine hydrochloride
Registered
Hospira TM Papaverine Hydrochloride Injection CMI Page 1 HOSPIRA TM PAPAVERINE HYDROCHLORIDE INJECTION Papaverine Hydrochloride (pa-PAV-er-een) CONSUMER MEDICINE INFORMATION _Date of Dispensing_ _Consumer Name _ _Pharmacist Name _ _Consumer Address _ _Pharmacist Address _ WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Hospira TM Papaverine Hydrochloride Injection. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor weighed the risks of you using papaverine against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT USING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET. You may need to read it again. WHAT HOSPIRA TM PAPAVERINE HYDROCHLORIDE INJECTION IS USED FOR This medicine is used to produce erections in impotent men. It belongs to a group of medicines called vasodilators. When papaverine is injected into the penis (called ‘intracavernosal’ injection) it works by increasing blood flow to the penis, which results in an erection. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY THIS PRODUCT HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed it for another reason. This medicine is not addictive. This medicine is available only with a doctor’s prescription. There is not enough information to recommend the use of this medicine for children and newborn babies. BEFORE YOU USE HOSPIRA™ PAPAVERINE HYDROCHLORIDE INJECTION _WHEN YOU MUST NOT USE IT _ DO NOT USE HOSPIRA™ PAPAVERINE HYDROCHLORIDE INJECTION IF YOU HAVE AN ALLERGY TO: any medicine containing papaverine any of the ingredients listed at the end of this leaflet. Symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty breathing; swelling of the face, lips, tongue or other parts of the body; rash, itching or hives on the skin. DO NOT USE THIS MEDICINE IF YOU HAVE ANY OF THE FOLLOWING MEDICAL CONDITIONS: complete at 阅读完整的文件
Product Information – Australia Version 1.0 Page 1 HOSPIRA™ PAPAVERINE HYDROCHLORIDE INJECTION NAME OF MEDICINE Papaverine hydrochloride The chemical structure is shown below. CAS registry number : 61-25-6 DESCRIPTION Papaverine hydrochloride is the hydrochloride of an alkaloid obtained from opium or prepared synthetically. It belongs to the benzylisoquinoline group of alkaloids. The chemical name for papaverine hydrochloride is 6,7-dimethoxy-1-veratrylisoquinoline hydrochloride. The molecular weight of papaverine hydrochloride (C 20 H 21 NO 4 ,HCl) is 375.9. Hospira™ Papaverine Hydrochloride Injection is a sterile, clear, colourless to pale-yellow solution of papaverine hydrochloride in water for injections. It is supplied in ampoules containing 30 mg or 120 mg of papaverine hydrochloride BP and water for injection BP/USP. The pH of the injection ranges between 3.0 and 5.0. PHARMACOLOGY The principal therapeutic action of papaverine hydrochloride is its relaxant effect on smooth muscles, which leads to penile erection. It may induce erections by arteriolar relaxation, increased blood flow and volume due to relaxation of the sinusoidal wall of the corpora cavernosa and subsequent compression of venous channels between the sinusoids and the tunica albuginea. The spasmolytic effect of papaverine hydrochloride is most pronounced on the vascular system, including coronary, cerebral, pulmonary and peripheral vasodilation; it also relaxes the bronchial, gastrointestinal, biliary and urinary tract smooth muscles. Papaverine hydrochloride has also been reported to have direct cardiac inotropic effects, leading to increased myocardial oxygen consumption, which can outstrip the effect of increased coronary blood flow if hypotension is also present. It can depress myocardial excitability, prolong the refractory period and depress myocardial conduction. In the presence of depressed conduction due to other causes (eg AV block), papaverine hydrochloride may produce transient ventricular arrhythmias. Papaverine hydrochlor 阅读完整的文件