GLIPIZIDE tablet

国家: 美国

语言: 英文

来源: NLM (National Library of Medicine)

有效成分:

GLIPIZIDE (UNII: X7WDT95N5C) (GLIPIZIDE - UNII:X7WDT95N5C)

可用日期:

McKesson Contract Packaging

INN（国际名称）:

GLIPIZIDE

组成:

GLIPIZIDE 5 mg

处方类型:

PRESCRIPTION DRUG

授权状态:

Abbreviated New Drug Application

产品特点

GLIPIZIDE- GLIPIZIDE TABLET
MCKESSON CONTRACT PACKAGING
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DESCRIPTION
Glipizide is an oral blood-glucose-lowering drug of the sulfonylurea
class.
The Chemical Abstracts name of glipizide is 1-cyclohexyl-3-[[p-[2-(5-
methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]urea. Its structural
formula is:
M.W. 4 4 5.55 C H N O S
Glipizide is a whitish, odorless powder with a pKa of 5.9. It is
insoluble in water and alcohols, but
soluble in 0.1 _N_ NaOH; it is freely soluble in dimethylformamide.
Each tablet, for oral administration,
contains 5 mg or 10 mg glipizide, USP.
Inactive ingredients are: colloidal silicon dioxide, lactose
(anhydrous), microcrystalline cellulose,
pregelatinized starch and stearic acid.
CLINICAL PHARMACOLOGY
MECHANISM OF ACTION
The primary mode of action of glipizide in experimental animals
appears to be the stimulation of insulin
secretion from the beta cells of pancreatic islet tissue and is thus
dependent on functioning beta cells in
the pancreatic islets. In humans glipizide appears to lower the blood
glucose acutely by stimulating the
release of insulin from the pancreas, an effect dependent upon
functioning beta cells in the pancreatic
islets. The mechanism by which glipizide lowers blood glucose during
long-term administration has not
been clearly established. In man, stimulation of insulin secretion by
glipizide in response to a meal is
undoubtedly of major importance. Fasting insulin levels are not
elevated even on long-term glipizide
administration, but the postprandial insulin response continues to be
enhanced after at least 6 months of
treatment. The insulinotropic response to a meal occurs within 30
minutes after an oral dose of glipizide
in diabetic patients, but elevated insulin levels do not persist
beyond the time of the meal challenge.
Extrapancreatic effects may play a part in the mechanism of action of
oral sulfonylurea hypoglycemic
drugs.
Blood sugar control persists in some patients for up to 24 hours after
a single dose of glipizide, even
though plasma levels have dec