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INDICATIONS [/za_1075.html#1]
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CONTRA-INDICATIONS [/za_1075.html#1]
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[/za_1075.html#1] PATIENT INFORMATION
FLOXAPEN 250 (CAPSULES)
FLOXAPEN S (SYRUP)
SCHEDULING STATUS:
S4
PROPRIETARY NAMES
(and dosage form):
FLOXAPEN 250 (CAPSULES)
FLOXAPEN S (SYRUP)
COMPOSITION:
FLOXAPEN 250
:
Gelatin capsules containing
FLUCLOXACILLIN
sodium equivalent to 250 mg flucloxacillin.
FLOXAPEN S:
Powder for preparing citrus-flavoured syrup.
When dispensed as directed, each 5 mL of the syrup contains flucloxacillin sodium equivalent to
125 mg flucloxacillin.
The powder contains 0,13% m/m sodium benzoate B.P. as a preservative.
PHARMACOLOGICAL CLASSIFICATION:
A.20.1.2 Penicillins
PHARMACOLOGICAL ACTION:
FLOXAPEN is a semi-synthetic penicillin derived from 6-amino-penicillanic acid and is the latest of the series of
penicillinase stable penicillins.
(A) BACTERIOLOGY
FLOXAPEN exhibits bactericidal activity against all Gram-positive organisms (with the exception of Strep. faecalis) e.g.
Haemolytic streptococci, staphylococci, streptococcus pneumoniae and N. gonorrhoeae.
FLOXAPEN’S anti-staphylococcal activity is not affected by penicillinase and as FLOXAPEN is active against virtually all
strains ofStaph. aureus (methicillin-resistant strains being the only exception), it is particularly indicated in the treatment
of staphylococcal infections.
The MIC’s of benzylpenicillin against staphylococci are lower than those of flucloxacillin except in the case of the
penicillinase-producing staphylococci.
(B) ABSORPTION
FLOXAPEN is ext
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