DYNAMET TABLET 200MG (FC)

国家: 马来西亚

语言: 英文

来源: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

有效成分:

CIMETIDINE

可用日期:

DYNAPHARM (M) SDN BHD

INN（国际名称）:

CIMETIDINE

每包单位数:

100 Tablets; 500 Tablets

厂商:

DYNAPHARM (M) SDN BHD

资料单张

Consumer Medication Information Leaflet (RiMUP)
DYNAMET TABLET
Cimetidine (200 mg, 400mg)
1
What is in this leaflet
1.
What DYNAMET TABLET is used
for
2.
How DYNAMET TABLET works
3.
Before you use DYNAMET
TABLET
4.
How to use DYNAMET TABLET
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of DYNAMET
TABLET
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
What DYNAMET TABLET is used
for
•
Duodenal and gastric ulcers.
•
Reflux oesophagitis (backflow of
stomach content into the esophagus
(food pipe).
•
Abnormal excessive secretion of
gastric acid such as Zollinger-Ellison
syndrome.
•
Pancreatic insufficiency.
How DYNAMET TABLET works
Cimetidine inhibits stimulation and
secretion of gastric acid and reduces
output of pepsin enzymes. Also, it
affects on the reduction secretion of body
fluids. Cimetidine also provide
protection to cells against harmful agents
and has a beneficial effect in maintaining
the gastric mucosal lining.
Before you use DYNAMET TABLET
-
When you must not use it
Do not use this medicine if:
•
You have lack or complete absence
of gastric juice.
•
You have abnormal growth and
proliferation of abnormal cells.
•
You are pregnant.
Pregnancy and lactation
Do not take DYNAMET TABLET if
you are pregnant, trying to get pregnant
or think you may be pregnant.
Cimetidine was detected in the breast
milk. Do not take DYNAMET TABLET
if you are breast-feeding. Ask your
doctor or pharmacist for advice before
taking any medicine.
-
Before you start use it
Tell your doctor or pharmacist if you
have impaired kidney function and
possibility of cancer should be excluded
before starting the treatment.
-
Taking other medicines
Tell your doctor if you are taking:
•
Lignocaine (local anaesthetic);
•
Phenytoin (prevent seizure);
•
Theophylline (prevent and treat
asthma);
•
Warfarin (prevent blood clotting); and
any other medicines, including any that
you buy without a prescription from a
pharmacy, supermarket or health food
shop.
How to use D

产品特点

DYNAMET TABLET
DESCRIPTION
CONTENT
DYNAMET TABLET 200MG
MAL19940254AZ
TABLET
Shape
:
Round, Biconvex & Scored
Colour
:
Light Green
Marking
:
“200”
Coating
:
Film-coated
Each Tablet Contains:
Cimetidine ..................................200 mg
DYNAMET TABLET 400MG
MAL19940492AZ
TABLET
Shape
:
Round, Biconvex & Scored
Colour
:
Light Green
Marking
:
“400”
Coating
:
Film-coated
Each Tablet Contains:
Cimetidine ..................................400 mg
PHARMACODYNAMICS:
Cimetidine inhibits both the stimulated and basal secretion of gastric
acid and reduces pepsin output. It competitively inhibits the action
of histamine at
the histamine H2-receptor of the parietal cells and thus is a
histamine H2-receptor antagonist. In addition to its antisecretory
effects, Cimetidine also
has cytoprotective properties and therefore has a beneficial effect in
maintaining the integrity of the gastric mucosal barrier.
PHARMACOKINETICS:
Cimetidine is readily absorbed from the gastrointestinal tract and
peak plasma concentrations are obtained about an hour after
administration on an
empty stomach and about 2 hours after administration with food.
The bioavailability of Cimetidine following oral administration is
about 60% to 70% compared to an intravenous dose due to first-pass
metabolism. The
elimination half-life from plasma is around 2 hours and Cimetidine is
weakly bound to about 20% to plasma proteins. Cimetidine is partially
metabolised
in the liver to the sulphoxide and to hydroxymethylcimetidine but most
is excreted unchanged in the urine. Cimetidine crosses the placental
barrier and
is excreted into breast milk where concentrations are reported to be
higher than those in plasma. It does not readily cross the blood brain
barrier.
INDICATIONS:
Duodenal and gastric ulcers. Reflux oesophagitis. Pathological
hypersecretory conditions such as Zollinger-Ellison syndrome.
Pancreatic insufficiency.
RECOMMENDED DOSE:
The dose should be adapted to each patient according to his
therapeutic response. The usual dose by mouth is 400 mg t