Drontal Dog Tasty Bone Tablets

国家: 马来西亚

语言: 英文

来源: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

有效成分:

FEBANTEL; PRAZIQUANTEL; PYRANTEL EMBONATE

可用日期:

ELANCO MALAYSIA SDN BHD

INN（国际名称）:

FEBANTEL; PRAZIQUANTEL; PYRANTEL EMBONATE

每包单位数:

102 Tablets

厂商:

KVP Pharma + Veterinar Produkte GmbH

资料单张

Blank document

产品特点

502170APK
Drontal Dog Tasty Bone
90208716
Leaflet
LBAH
N/A
90204269
140 x 180 mm
N/A
TPM_016702
7 pt
ORT / MK / 05.04.2022
V1
Laetus: 0008
N/A
BLACK
DIE LINE
Page 1 of 2
90208716
Dog Tasty Bone Tablets
PRODUCT DESCRIPTION
DRONTAL DOG TASTY BONE TABLETS is light brown to brown colour,
meat-flavoured, bone-shaped tablet. Each tablet contains 150
mg of febantel, 144 mg of pyrantel embonate and 50 mg of
praziquantel.
PHARMACODYNAMICS
The product is an anthelmintic containing as active substances
the tetrahydropyrimidine derivative pyrantel (as the embonate
salt), the pro-benzimidazole febantel and praziquantel, a partly
hydrogenated pyrazinoisoquinoline derivative. It is effective
against certain roundworms and tapeworms.
In this fixed combination pyrantel and febantel act
synergistically against roundworms (ascarids, hookworms and
whipworms) in dogs. In particular, the action spectrum covers
Toxocara canis, Toxascaris leonina, Uncinaria stenocephala,
Ancylostoma caninum
and
Trichuris vulpis.
The spectrum of activity of praziquantel covers tapeworm
species in dogs. In particular, it includes all
Taenia
species, as
well as
Multiceps multiceps, Dipylidium caninum , Echinococcus
granulosus
and
Echinococcus multilocularis
. Praziquantel acts
against all intestinal stage of these parasites.
Pyrantel acts like nicotine as a cholinergic agonist, causing
spastic paralysis of roundworms via a depolarizing
neuromuscular block.
The anthelmintic efficacy of febantel is due to its ability to
inhibit the polymerization of tubulin to microtubuli. The
resulting structural and functional metabolic disturbances
exhaust the parasite’s energy reserves and kill it in 2-3 days.
Praziquantel is absorbed very rapidly through the parasite’s
surfaces and is evenly distributed throughout their bodies. It
causes severe damage of their integument, leading to disruption
of metabolism and thence to death.
PHARMACOKINETICS
Praziquantel is absorbed almost completely in the small
intestine following oral administration to dogs. Absorption is
very