产品特点
Diclocil Capsules V3.0
PRODUCT INFORMATION
DICLOCIL
®
(DICLOXACILLIN SODIUM)
CAPSULES
NAME OF THE DRUG
Dicloxacillin sodium is sodium
(6R)-6-[3-(2,6-dichlorophenyl)-5-methylisoxazole-4-
carboxamido]-penicillanate monohydrate; it is a
penicillinase-resistant, acid-resistant,
semisynthetic penicillin with the following structure.
DESCRIPTION
Dicloxacillin sodium is a white or off-white crystalline powder.
Diclocil capsules contain dicloxacillin sodium equivalent to 500mg dicloxacillin. Inactive
ingredients are magnesium stearate, silica colloidal anhydrous,
gelatin and titanium dioxide.
PHARMACOLOGY
_Pharmacokinetics:_
Dicloxacillin is resistant to destruction by acid. Absorption from the gastrointestinal tract is
rapid, in fasting adults, 50% to 94% of an oral dose was absorbed with peak serum levels reached
within 0.5 to 2 hours. Food in the gastrointestinal tract decreases the absorption of dicloxacillin.
Serum levels after oral administration are directly proportional to dosage at unit doses of 125mg,
250mg, and 500mg as measured at the 2-hour level. Single oral
doses of dicloxacillin 500 mg
produced peak serum concentrations of 10 to 18 _µ_g/mL.
Dicloxacillin is 95% to 99% bound to serum proteins, mainly albumin. Dicloxacillin is
distributed into bone, bile, pleural fluid, and synovial fluid. Only minimal concentrations are
attained in cerebrospinal fluid.
The elimination half-life of dicloxacillin is approximately 0.7 hours. Dicloxacillin is
partially
metabolized to microbiologically active (5-hydroxymethyl derivative of dicloxacillin) and
Diclocil Capsules V3.0
2
inactive metabolites. Dicloxacillin and its metabolites are rapidly excreted in the ur
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