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DIAMOX- Product Information
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PRODUCT INFORMATION
DIAMOX
®
ACETAZOLAMIDE TABLETS
_ _
DESCRIPTION
DIAMOX (acetazolamide) is a carbonic anhydrase inhibitor. It is N-(5-sulphamoyl-1,3,4-
thiadiazole-2-yl acetamide and its structural formula is:
N
H
O
N
N
S
S
NH
2
O
O
H
3
C
CAS No. 59-6-5
It is a white to yellowish-white crystalline substance,
sparingly soluble in cold water with a mp of
258-259
C, a weak acid, a pKa of 7.2 and a molecular weight of 222.25
(C
4
H
6
N
4
O
3
S
2
).
DIAMOX tablets contain the active ingredient acetazolamide as well as the following excipients:
sodium starch glycollate, povidone, calcium phosphate,
starch-maize and magnesium stearate.
PHARMACOLOGY
_MECHANISM OF ACTION _
DIAMOX is a nonbacteriostatic sulfonamide possessing a chemical structure and
pharmacological activity distinctly different from
the bacteriostatic sulfonamides.
DIAMOX is an enzyme inhibitor that acts specifically on carbonic anhydrase, the enzyme that
catalyses the reversible reaction involving the hydration of carbon dioxide and the dehydration of
carbonic acid. In the eye this inhibitory action of acetazolamide decreases the secretion of
aqueous humour and results in a drop in intraocular pressure, a reaction considered desirable in
cases of glaucoma and even in certain nonglaucomatous conditions. Evidence seems to indicate
that DIAMOX has utility as an adjuvant in the treatment of certain dysfunctions of the central
nervous system (e.g. epilepsy). Inhibition of carbonic anhydrase in this area appears to retard
abnormal, paroxysmal, excessive discharge from central nervous s
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