Desflurane volatile liquid

国家: 英国

语言: 英文

来源: MHRA (Medicines & Healthcare Products Regulatory Agency)

有效成分:

Desflurane

可用日期:

Baxter Healthcare Ltd

ATC代码:

N01AB07

INN（国际名称）:

Desflurane

剂量:

1ml/1ml

药物剂型:

Inhalation vapour

给药途径:

Inhalation

类:

No Controlled Drug Status

处方类型:

Valid as a prescribable product

產品總結:

BNF: 15010200; GTIN: 00085412586595

产品特点

OBJECT 1
DESFLURANE 100% V/V INHALATION VAPOUR, LIQUID
Summary of Product Characteristics Updated 05-Mar-2018 | Baxter
Healthcare Ltd
1. Name of the medicinal product
Desflurane 100% v/v Inhalation vapour, liquid
2. Qualitative and quantitative composition
Desflurane, supplied as pure drug substance.
3. Pharmaceutical form
Inhalation vapour, liquid
4. Clinical particulars
4.1 Therapeutic indications
Desflurane is indicated as an inhalation agent for induction and/or
maintenance of anaesthesia for
inpatient and outpatient surgery in adults and maintenance of
anaesthesia for inpatient and outpatient
paediatric surgery.
4.2 Posology and method of administration
Method of administration
Desflurane is administered by inhalation.
Desflurane should only be administered by persons trained in the
administration of general anaesthesia
using a vaporizer specifically designed and designated for use with
desflurane.
Premedication
Premedication should be selected according to the needs of the
individual patient taking into account that
salivary secretions are stimulated. The use of anticholinergic drugs
is a matter of choice for the
anaesthetist.
Individualization
The administration of general anaesthesia must be individualized based
on the patient's response.
Effects on Concomitant Therapy
Opioids or benzodiazepines decrease the amount of desflurane required
to produce anaesthesia.
Desflurane decreases the required doses of neuromuscular blocking
agents (see Table 2, section 4.5). If
added relaxation is required, supplemental doses of muscle relaxants
may be used. (See section 4.5)
Dosage
The minimum alveolar concentration (MAC) of desflurane decreases with
increasing patient age. The
dose of desflurane should be adjusted accordingly. The MAC has been
determined as listed in Table 1.
Table 1
MAC for desflurane according to patient age and inhalation mixture
(Mean±SD)
Age
N*
100% Oxygen
N*
60% Nitrous Oxide/40%
Oxygen
2 weeks
6
9.2±0.0
-
-
10 weeks
5
9.4±0.4
-
-
9 months
4
10.0±0.7
5
7.5±0.8
2 years
3
9.1±0.6
-
-
3 years