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CIPRAMIL
®
(SIP-RA-MIL)
_Citalopram hydrobromide (sigh-TALO-pram high-dro-BRO-mide)_
CONSUMER MEDICINE INFORMATION (CMI)
WHAT IS IN THIS LEAFLET
This leaflet contains answers to some
common questions about Cipramil.
It does not contain all the information
that is known about Cipramil. It does
not take the place of talking to your
doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risk of you using this medicine
against the benefits he/she expects it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
USING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT CIPRAMIL IS USED
FOR
Cipramil is used to treat depression.
It belongs to a group of medicines
called selective serotonin reuptake
inhibitors (SSRIs). They are thought
to work by their actions on brain
chemicals called amines which are
involved in controlling mood.
Depression is longer lasting or more
severe than the "low moods"
everyone has from time to time due
to the stress of everyday life. It is
thought to be caused by a chemical
imbalance in parts of the brain. This
imbalance affects your whole body
and can cause emotional and physical
symptoms such as feeling low in
spirit, loss of interest in activities,
being unable to enjoy life, poor
appetite or overeating, disturbed
sleep, often waking up early, loss of
sex drive, lack of energy and feeling
guilty over nothing.
Cipramil corrects this chemical
imbalance and may help relieve the
symptoms of depression.
Your doctor, however, may prescribe
it for another purpose.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY IT HAS BEEN
PRESCRIBED FOR YOU.
This medicine is only available with
a doctor's prescription.
Cipramil is not addictive. However,
if you suddenly stop taking it, you
may get side effects.
TELL YOUR DOCTOR IF YOU GET ANY SIDE
EFFECTS AFTER STOPPING CIPRAMIL.
BEFORE YOU TAKE IT
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE CIPRAMIL IF YOU HAVE A
CONDITION CALLED 'CONGENITAL LONG
QT S
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_Cipramil PI 24/5/13 v3 _
PRODUCT INFORMATION
CIPRAMIL
®
FILM-COATED TABLETS
NAME OF THE MEDICINE
Citalopram hydrobromide
Chemical name:
1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
hydrobromide. The active is present as a racemate.
CAS number:
[59729-32-7]
Molecular formula:
C
20
H
21
FN
2
O, HBr
Molecular weight:
405.32
Structural formula:
DESCRIPTION
Citalopram hydrobromide is
a fine white to off-white, crystalline material.
Citalopram hydrobromide is sparingly soluble in water, soluble in ethanol (96%), freely
soluble in chloroform and very slightly soluble in diethylether. No polymorphic forms have
been detected.
Cipramil 20mg tablets are oval,
white, scored, film-coated tablets_ _marked "C" and "N".
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_Cipramil PI 24/5/13 v3 _
The tablets contain the following excipients: starch - maize, lactose, cellulose -
microcrystalline, PVP/VA copolymer, glycerol, croscarmellose sodium, magnesium
stearate, hypromellose, macrogol 400 and titanium dioxide.
PHARMACOLOGY
Pharmacological actions
Biochemical and behavioural studies have shown that citalopram is a potent inhibitor of
serotonin (5-HT)-uptake. Tolerance to the inhibition of 5-HT-uptake is not induced by
long-term treatment with citalopram.
On the basis
of in vitro studies, citalopram is one of the most selective Serotonin Reuptake
Inhibitor (SSRI) yet developed, with no, or minimal
effect on noradrenaline (NA), dopamine
(DA) and gamma aminobutyric acid (GABA) uptake. In comparison with other SSRIs the
decreasing order of selectivity is escitalopram, citalopram, sertraline, paroxetine,
f
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