CHLORZOXAZONE tablet

国家: 美国

语言: 英文

来源: NLM (National Library of Medicine)

有效成分:

Chlorzoxazone (UNII: H0DE420U8G) (Chlorzoxazone - UNII:H0DE420U8G)

可用日期:

Cameron Pharmaceuticals

给药途径:

ORAL

处方类型:

PRESCRIPTION DRUG

疗效迹象:

Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Chlorzoxazone does not directly relax tense skeletal muscles in man. Chlorzoxazone is contraindicated in patients with known intolerance to the drug.

產品總結:

Chlorzoxazone Tablets, USP 500 mg for Oral administration are supplied as follows, White to off-white capsule shaped tablets debossed with N085 on the bisected side: Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Dispense contents with a child-resistant closure (as required) and in a tight container as defined in the USP/NF.

授权状态:

Abbreviated New Drug Application

产品特点

CHLORZOXAZONE- CHLORZOXAZONE TABLET
CAMERON PHARMACEUTICALS
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CHLORZOXAZONE TABLETS, USP 500 MG
DESCRIPTION
Chlorzoxazone USP is a centrally acting skeletal muscle relaxant,
available as tablets of 500 mg for
oral administration. Its chemical name is 5-Chloro-2-benzoxazolinone,
and its structural formula is:
C H CINO
MW 169.57
Chlorzoxazone USP is a white or practically white, practically
odorless, crystalline powder.
Chlorzoxazone is slightly soluble in water; sparingly soluble in
alcohol, in isopropyl alcohol, and in
methanol; soluble in solutions of alkali hydroxides and ammonia.
Chlorzoxazone tablets contain the inactive ingredients Pregelatinized
Starch, Croscarmellose Sodium,
Microcrystalline Cellulose, Docusate Sodium, Sodium Benzoate,
Colloidal Silicon dioxide,
Magnesium Stearate.
CLINICAL PHARMACOLOGY
Chlorzoxazone is a centrally-acting agent for painful musculoskeletal
conditions. Data available from
animal experiments as well as human study indicate that chlorzoxazone
acts primarily at the level of the
spinal cord and subcortical areas of the brain where it inhibits
multisynaptic reflex arcs involved in
producing and maintaining skeletal muscle spasm of varied etiology.
The clinical result is a reduction
of the skeletal muscle spasm with relief of pain and increased
mobility of the involved muscles. Blood
levels of chlorzoxazone can be detected in people during the first 30
minutes and peak levels may be
reached, in the majority of the subjects, in about 1 to 2 hours after
oral administration of chlorzoxazone.
Chlorzoxazone is rapidly metabolized and is excreted in the urine,
primarily in a conjugated form as the
glucuronide. Less than one percent of a dose of chlorzoxazone is
excreted unchanged in the urine in 24
hours.
INDICATIONS
Chlorzoxazone is indicated as an adjunct to rest, physical therapy,
and other measures for the relief of
discomfort associated with acute, painful musculoskeletal conditions.
The mode of action of this drug
has not been clearly identified, but may be related to its