CARPROFEN tablet, chewable

国家: 美国

语言: 英文

来源: NLM (National Library of Medicine)

有效成分:

CARPROFEN (UNII: FFL0D546HO) (CARPROFEN - UNII:FFL0D546HO)

可用日期:

FELIX PHARMACEUTICALS PRIVATE LIMITED

给药途径:

ORAL

处方类型:

PRESCRIPTION

疗效迹象:

Carprofen Tablets are indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs. Carprofen Tablets should not be used in dogs exhibiting previous hypersensitivity to carprofen.

產品總結:

Carprofen Tablets are scored, and contain 25 mg, 75 mg, or 100 mg of carprofen per tablet. Each tablet size is packaged in bottles containing 30, 60, or 180 tablets.

授权状态:

Abbreviated New Animal Drug Application

产品特点

CARPROFEN- CARPROFEN TABLET, CHEWABLE
FELIX PHARMACEUTICALS PRIVATE LIMITED
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CARPROFEN TABLETS
FLAVORED TABLETS
NON-STEROIDAL ANTI-INFLAMMATORY DRUG
FOR ORAL USE IN DOGS ONLY
CAUTION
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION
Carprofen is a non-steroidal anti-inflammatory drug (NSAID) of the
propionic acid class
that includes ibuprofen, naproxen, and ketoprofen. Carprofen is the
nonproprietary
designation for a substituted carbazole,
6-chloro-α-methyl-9H-carbazole-2-acetic acid.
The empirical formula is C
H
CINO and the molecular weight 273.72. The chemical
structure of carprofen is:
Carprofen is a white, crystalline compound. It is freely soluble in
ethanol, but practically
insoluble in water at 25ºC.
CLINICAL PHARMACOLOGY
Carprofen is a non-narcotic, non-steroidal anti-inflammatoryagent with
characteristic
analgesic and antipyretic activity approximately equipotent to
indomethacin in animal
models.
The mechanism of action of carprofen, like that of other NSAIDs, is
believed to be
associated with the inhibition of cyclooxygenase activity. Two unique
cyclooxygenases
have been described in mammals.
The constitutive cyclooxygenase, COX-1,
synthesizes prostaglandins necessary for normal gastrointestinal and
renal function.
The inducible cyclooxygenase, COX-2, generates prostaglandins involved
in
inflammation. Inhibition of COX-1 is thought to be associated with
gastrointestinal and
renal toxicity while inhibition of COX-2 provides anti-inflammatory
activity. The specificity
of a particular NSAID for COX-2 versus COX-1 may vary from species to
species.
In an
_in vitro_ study using canine cell cultures, carprofen demonstrated
selective inhibition of
COX-2 versus COX-1.
Clinical relevance of these data has not been shown. Carprofen
15
12
2
1
2
3
4
has also been shown to inhibit the release of several prostaglandins
in two inflammatory
cell systems: rat polymorphonuclear leukocytes (PMN) and human
rheumatoid synovial
cells, indicating inhibition of acute