Carlovell Tablets 25 mg

国家: 马来西亚

语言: 英文

来源: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

有效成分:

CARVEDILOL

可用日期:

AVERROES PHARMACEUTICALS SDN. BHD.

INN（国际名称）:

CARVEDILOL

每包单位数:

30tablet Tablets

厂商:

PT NOVELL PHARMACEUTICAL LABORATORIES.

产品特点

CARLOVELL TABLET 25 MG
CARVEDILOL 25 MG
PRODUCT DESCRIPTION
Film coated tablet, round, convex, break line on one side, white,
odorless and tasteless.
COMPOSITION
Each film coated tablet contains 25 mg of Carvedilol
PHARMACODYNAMICS
Carvedilol is a multiple action adrenergic receptor blocker with α1,
β1 and β2 adrenergic
receptor blockade properties. Carvedilol has been shown to have
organ-protective effects.
Carvedilol is a potent antioxidant and a scavenger of reactive oxygen
radicals. Carvedilol
is racemic, and both R(+) and S(-) enantiomers have the same
α-adrenergic receptor
blocking properties and antioxidant properties. Carvedilol has
antiproliferative effects on
human vascular smooth muscle cells. A decrease in oxidative stress has
been shown in
clinical studies by measuring various markers during chronic treatment
of patients with
carvedilol.
Carvedilol’s β-adrenergic receptor blocking properties are
non-selective for the β1 and
β2-adrenoceptors and are associated with the levorotatory S(-)
enantiomer. Carvedilol has
no intrinsic sympathomimetic activity and (like propranolol) it has
membrane stabilising
properties. Carvedilol suppresses the renin-angiotensin-aldosterone
system through β-
blockade, which reduces the release of renin, thus making fluid
retention rare. Carvedilol
reduces the peripheral vascular resistance via selective blockade of
α1-adrenoceptors.
Carvedilol attenuates the increase in blood pressure induced by
phenylephrine, an α1-
adrenoceptor agonist, but not that induced by angiotensin II.
Carvedilol has no adverse
effect on the lipid profile. A normal ratio of high-density
lipoproteins to low density
lipoproteins (HDL/LDL) is maintained.
PHARMACOKINETICS
_Absorption _
Following oral administration, carvedilol is rapidly absorbed.
Carvedilol is a substrate of the
intestinal efflux transporter P-glycoprotein which plays a major role
in the bioavailability of
certain drugs. In healthy volunteers the maximum serum concentration
is reached after
approximately
one
hour.
The
absol