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CARDIFEN™ –5 CAPSULES
CARDIFEN™ –10 CAPSULES
D167
SCHEDULING STATUS:
S3
PROPRIETARY NAME
(and dosage form):
CARDIFEN™ –5 CAPSULES
CARDIFEN™ –10 CAPSULES
COMPOSITION:
Each capsule contains 5 mg or 10 mg
Nifedipine
.
PHARMACOLOGICAL CLASSIFICATION:
A 7.1.4 Vasodilators –coronary and other medicines used in angina pectoris.
PHARMACOLOGICAL ACTION:
Cardifen is a calcium antagonist which inhibits excitation - contraction coupling in myocardial and smooth muscle by
blocking the transmembrane carrier of calcium. This results in vasodilation as well as decreased myocardial contractility
and myocardial oxygen demand. Cardifen is also reported to act by reducing peripheral resistance.
After oral administration of Cardifen, peripheral blood flow increases due to arterial dilatation. There is no change in
venous tone. The increase in cardiac output is due to a decrease in arteriolar resistance coupled with the positive
inotropic effect that results from the expected sympathetic reflexes.
Recent evidence suggests that sublingual Cardifen produces a more marked improvement in cardiac performance in
patients with poor ventricular function (but without failure) than it does in patients with normal ventricular function.
INDICATIONS:
Treatment and prophylaxis of angina pectoris.
CONTRA-INDICATIONS:
The safety of Cardifen in pregnancy has not been established. The administration of Cardifen is contra-indicated in
patients with porphyria.
WARNING:
In patients who experience ischaemic pain following administration of Cardifen, therapy should be discontinued.
DOSAGE AND DIRECTIONS FOR USE:
The usual oral dose is 10 mg thrice daily taken during or after meals increased, if necessary, to 20 mg thrice daily. A
recommended dose for elderly patients or those on concomitant medication is
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