CARDALIS- spironolactone and benazepril hydrochloride tablet, chewable

国家: 美国

语言: 英文

来源: NLM (National Library of Medicine)

有效成分:

SPIRONOLACTONE (UNII: 27O7W4T232) (SPIRONOLACTONE - UNII:27O7W4T232), BENAZEPRIL HYDROCHLORIDE (UNII: N1SN99T69T) (BENAZEPRILAT - UNII:JRM708L703)

可用日期:

Ceva Sante Animale

给药途径:

ORAL

处方类型:

PRESCRIPTION

疗效迹象:

CARDALIS is indicated with concurrent therapy (e.g. furosemide, etc.) for the management of clinical signs of mild, moderate, or severe congestive heart failure in dogs due to atrioventricular valvular insufficiency (AVVI). Do not administer CARDALIS in conjunction with non-steroidal anti-inflammatory drugs (NSAIDs) in dogs with renal insufficiency. Do not administer CARDALIS to dogs with hypoadrenocorticism (Addison’s Disease), hyperkalemia, or hyponatremia. Do not administer CARDALIS to animals with known hypersensitivity to ACE inhibitors or spironolactone.

產品總結:

CARDALIS chewable tablets for dogs are available in 3 sizes of oblong half scored flavored tablets: 20 mg spironolactone and 2.5 mg benazepril hydrochloride, 40 mg spironolactone and 5 mg benazepril hydrochloride, and 80 mg spironolactone and 10mg benazepril hydrochloride. Each size is available in 30-count bottles enclosed in color coded packages.

授权状态:

New Animal Drug Application

产品特点

CARDALIS- SPIRONOLACTONE AND BENAZEPRIL HYDROCHLORIDE TABLET, CHEWABLE
CEVA SANTE ANIMALE
----------
CARDALIS™
(spironolactone and benazepril hydrochloride chewable tablets)
Cardiac drug for oral use in dogs only
Approved by FDA under NADA # 141-538
CAUTION: Federal (USA) law restricts this drug to use by or on the
order of a licensed
veterinarian.
DESCRIPTION:
CARDALIS (spironolactone and benazepril hydrochloride chewable
tablets) for dogs
contains two active ingredients, spironolactone and benazepril
hydrochloride, in a fixed
ratio of 8:1 respectively. CARDALIS is supplied as oblong half scored
flavored chewable
tablets in three sizes:
20 mg spironolactone and 2.5 mg benazepril hydrochloride, 40 mg
spironolactone and 5
mg benazepril hydrochloride, and 80 mg spironolactone and 10 mg
benazepril
hydrochloride.
Benazepril belongs to the angiotensin-converting enzyme (ACE)
inhibitor class of drugs.
Benazepril hydrochloride empirical formula is C
H
N O · HCl and the molecular weight
is 460.95. The chemical name is
3-[[1-(ethoxy-carbonyl)-3-phenyl-(1S)-propyl]amino]-
2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benazepine-1-acetic acid
monohydrochloride and
the structural formula is shown below:
Spironolactone, and its active metabolites, act as specific
aldosterone antagonists.
Spironolactone empirical formula is C
H
O S and the molecular weight is 416.57. The
chemical name is
17-hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid
y-lactone acetate and the structural formula is shown below:
24
28
2
5
24
32
4
INDICATIONS:
CARDALIS is indicated with concurrent therapy (e.g. furosemide, etc.)
for the
management of clinical signs of mild, moderate, or severe congestive
heart failure in
dogs due to atrioventricular valvular insufficiency (AVVI).
DOSAGE AND ADMINISTRATION:
CARDALIS administration should begin after pulmonary edema is
stabilized. CARDALIS
should be administered orally once daily at a dose of 0.9 mg/lb (2
mg/kg) spironolactone
and 0.11 mg/lb (0.25 mg/kg) benazepril hydrochloride, according to dog
body we