国家: 亚美尼亚
语言: 英文
来源: Դեղերի և բժշկական տեխնոլոգիաների փորձագիտական կենտրոնի գործունեության Հայաստանի Հանրապետությունում
metamizole (metamizole sodium)
Arpimed LLC
N02BB02
metamizole (metamizole sodium)
500mg
tablets
(200/20x10/) in blister
OTC
Registered
2019-11-22
SUMMARY PRODUCT CHARACTERISTIC (SPC) ANALGIN GIGAFARM 500 MG TABLETS BRAND NAME – ANALGIN GIGAfarm GENERIC NAME – Metamizole sodium (Dipyrone) COMPOSITION Each tablet_ _contains: _ACTIVE INGREDIENT: _metamizole sodium – 500 mg; _INACTIVE INGREDIENTS:_ microcrystalline cellulose, lactose monohydrate, maize starch, sodium starch glycolate, magnesium stearate, talc purified. PHARMACOLOGICAL GROUP AND ATC CODE Analgesic-antipyretic; N02BB02. PHARMACOLOGY ANALGIN (metamizole) is a medicine of the pyrazolone group, possessing hard analgesic and antipyretic effects and moderate antiinflammatory activity. Blocking of the synthesis of endogenous pyrogens - prostaglandins D and E - is the cause for the antipyretic activity and also for the analgesic action of this drug. The decrease of the prostaglandis production in the periphery (and respective decrease of nerve endings sensitivity) plays a relatively smaller role. In contrast to the other nonnarcotic analgesic drugs, metamizole stimulates the release of β-endorphins, explaining its activity in cases of visceral pain. Metamizole has a slight spasmolytic activity on the smooth muscle cells of the biliary and urinary tracts and also on the muscle of the uterus. PHARMACOKINETICS After oral doses metamizole is rapidly hydrolysed in gastric juice to the active metabolite 4-methyl- amino-antipyrine which after absorption undergoes metabolism to 4- methyl-amino-antipyrine and other metabolites. None of the metabolites of metamizole are extensively bound to plasma proteins. Most of a dose is excreted in the urine as metabolites. Metamizole metabolites are also distributed into breast milk. Action develops in 20-40 minutes and reaches to the maximum after 2 h. USES ANALGIN GIGAfarm tablets are used for the treatment of pains of different origin and variable intensity: - toothache, headache, arthralgia, neuralgia, myalgia (in case of other analgesic medications inefficiency); - fever with colds and infectious-inflammatory diseases. ADMINISTRATION The dosage and duration of 阅读完整的文件