国家: 台湾
语言: 中文
来源: 衛生福利部食品藥物管理署 (Ministry of Health and Welfare, Food And Drug Administration)
Ranolazine
東生華製藥股份有限公司 台北市南港區園區街3之1號3樓之1 (53093421)
C01EB18
持續性藥效錠
Ranolazine (2800100100) MG
PVC/ACLAR-AL 鋁箔盒裝
製 劑
須由醫師處方使用
LUPIN LIMITED 15B, PHASE1A, VERNA INDUSTRIAL AREA, VERNA, GOA-403722, INDIA IN
ranolazine
治療穩定心絞痛(stable angina):已使用第一線心絞痛藥(如β受體阻斷劑及/或鈣離子阻斷劑)未能適當控制或無法耐受第一線心絞痛用藥的穩定心絞痛(stable angina)病人,ranolazine可作為併用或替代治療以改善症狀。
有效日期: 2025/03/16; 英文品名: Rancad Extended Release Tablets 1000mg
2020-03-16
500 027827 Rancad ® Extended Release Tablets 500 mg 1000 027828 Rancad ® Extended Release Tablets 1000 mg 1 stable angina β stable angina Ranolazine 2 2.1 500 1000 1000 2 2.2 [ 7.1 ] CYP3A diltiazem verapamil erythromycin 500 CYP3A [ 47.1 ] P- P-gp inhibitors cyclosporine [ 7.1 ] 3 • 500 L31 LU • 1000 L32 LU 4 • CYP3A [ 7.1 ] • CYP3A [ 7.1 ] • [ 8.5 ] 5 ( ) 5.1 QT Ranolazine I kr QTc proarrhythmia [ 13.2 ] Ranolazine > 1000 QT potassium channel variants QT QT QT QT 5.2 CrCL<30mL/min Ranolazine ( ) Ranolazine [ 8.6 ] CrCL<60mL/min Ranolazine Ranolazine 6 ( ) 6.1 2,018 Ranolazine Ranolazine 1,026 CARISAERICAMARISA 12 1,251 Ranolazine Ranolazine 1 1,227 2 613 3 531 4 326 Ranolazine 6% 3% Ranolazine 1.3% vs 0.1% 1% vs 0% 0.5% vs 0% 1000 > 4% Ranolazine 6.2% 5.5% 4.5% 4.4% Ranolazine 0.5%-4% – – – – – – – – – – – – <0.5% Ranolazine Ranolazine proarrhythmic effect [ 13.2 ] Ranolazine 0.1 mg/dL Ranolazine Ranolazine BUN Ranolazine 1000 RanolazineBUN [ 5.2 (8.6) ] 6.2 Ranolazine – Ranolazine Ranolazine – – – – 7 ( ) 7.1 RANOLAZINE CYP3A Ranolazine CYP3A ketoconazoleitraconazole clarithromycin nefazodone nelfinavir ritonavirindinavir saquinavir [ 411.3 ] CYP3A CYP3A Ranolazine 500 CYP3A diltiazem verapamil erythromycin fluconazole [ 2.211.3 ] P- P-GP INHIBITORS Ranolazine P- cyclosporine Ranolazine P- cyclosporine Ranolazine [ 2.2 ] CYP3A Ranolazine CYP3A rifampinrifabutinrifapentin phenobarbital phenytoin carbamazepine (St. John s wort) [ 411.3 ] 7.2 RANOLAZINE CYP3A simvastatin Ranolazine Ranolazine simvastatin 20 CYP3A lovastatin CYP3A cyclosporinetacrolimus sirolimus Ranolazine [ 11.3 ] P- P-GP Ranolazine digoxin digoxin digoxin [ 11.3 ] CYP2D6 Ranolazine CYP2D6 OCT2 Ranolazine 1000 metformin metformin Ranolazine 1000 metformin 1700 metformin Ranolazine 500 metformin metformin [ 11.3 ] 8 ( ) 8.1 Ranolazine MRHD 4 2-4% 15-20% - Ranolazine AUC MRHD 4 MRHD AUC 8.2 Ranolazine Ranolazine [ 8.1 ] Ranolazine Ranolazine 6 20 Ranolazine 60 mg/kg/day AUC MRHD Ranolazine 8.3 8.4 阅读完整的文件