VISKEN- pindolol tablet

Quốc gia: Hoa Kỳ

Ngôn ngữ: Tiếng Anh

Nguồn: NLM (National Library of Medicine)

Thành phần hoạt chất:

PINDOLOL (UNII: BJ4HF6IU1D) (PINDOLOL - UNII:BJ4HF6IU1D)

Sẵn có từ:

Novartis Pharmaceuticals Corporation

INN (Tên quốc tế):

pindolol

Dạng dược phẩm:

TABLET

Thành phần:

5 mg

Tuyến hành chính:

ORAL

Loại thuốc theo toa:

PRESCRIPTION DRUG

Chỉ dẫn điều trị:

Visken® (pindolol) is indicated in the management of hypertension. It may be used alone or concomitantly with other antihypertensive agents, particularly with a thiazide-type diuretic. Visken® (pindolol) is contraindicated in: 1) bronchial asthma; 2) overt cardiac failure; 3) cardiogenic shock; 4) second and third degree heart block; 5) severe bradycardia. (See WARNINGS)

Tóm tắt sản phẩm:

White, uncoated, heart-shaped tablets; 5 mg and 10 mg, packages of 100. 5 mg tablets engraved “VISKEN 5’’ on one side, and embossed “V’’ on other side (NDC 0078-0111-05). 10 mg tablets engraved “VISKEN 10’’ on one side, and embossed “V’’ on other side (NDC 0078-0073-05). Below 86°F (30°C); tight, light-resistant container. Manufactured by: Novartis Pharmaceuticals Canada Inc. Dorval (Quebec) Canada H9R 4P5 Distributed by: Novartis Pharmaceuticals Corporation East Hanover, New Jersey 07936 REV: NOVEMBER 1998                         T1999-39 89003701 2162-25-99A ©1998 Novartis

Đặc tính sản phẩm

VISKEN- PINDOLOL TABLET
NOVARTIS PHARMACEUTICALS CORPORATION
----------
VIS KEN
T1999-39
89003701 VISKEN
_ (pindolol)_
_ tablets, USP_ RX ONLY
DESCRIPTION
Visken (pindolol), a synthetic beta-adrenergic receptor blocking agent
with intrinsic sympathomimetic
activity is 1-(Indol-4-yloxy)-3-(isopropylamino)-2-propanol.
Its structural formula is:
Pindolol is a white to off-white odorless powder soluble in organic
solvents and aqueous acids.
Visken (pindolol) is intended for oral administration.
_5 MG AND 10 MG TABLETS_
_Active Ingredient:_ pindolol
_Inactive Ingredients:_ colloidal silicon dioxide, magnesium stearate,
microcrystalline cellulose, and
pregelatinized starch.
®
®
®
®
CLINICAL PHARMACOLOGY
Visken (pindolol) is a non-selective beta-adrenergic antagonist
(beta-blocker) which possesses
intrinsic sympathomimetic activity (ISA) in therapeutic dosage ranges
but does not possess quinidine-
like membrane stabilizing activity.
PHARMACODYNAMICS
In standard pharmacologic tests in man and animals, Visken (pindolol)
attenuates increases in heart rate,
systolic blood pressure, and cardiac output resulting from exercise
and isoproterenol administration,
thus confirming its beta-blocking properties. The ISA or partial
agonist activity of Visken (pindolol)
is mediated directly at the adrenergic receptor sites and may be
blocked by other beta-blockers. In
catecholamine-depleted animal experiments, ISA is manifested as an
increase in the inotropic and
chronotropic activity of the myocardium. In man, ISA is manifested by
a smaller reduction in the resting
heart rate (4-8 beats/min) than is seen with drugs lacking ISA. There
is also a smaller reduction in
resting cardiac output. The clinical significance of this observation
has not been evaluated and there is
no evidence, or reason to believe, that exercise cardiac output is
less affected by Visken (pindolol).
Visken (pindolol) has been shown in controlled, double-blind clinical
studies to be an effective
antihypertensive agent when used as monotherapy, or when added to
t