Tritace

Quốc gia: Úc

Ngôn ngữ: Tiếng Anh

Nguồn: Department of Health (Therapeutic Goods Administration)

Thành phần hoạt chất:

Ramipril

Sẵn có từ:

Sanofi-Aventis Australia Pty Ltd

Lớp học:

Medicine Registered

Tờ rơi thông tin

TRITACE
®

(TRY-TASE)
_Ramipril (RAM-(m)e-pril)_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Tritace.
It does not contain all the available
information about this medicine.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Tritace against
the benefits they expect it will have
for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT TRITACE IS USED
FOR
Tritace belongs to a group of
medicines called angiotensin
converting enzyme (ACE) inhibitors.
Tritace is used to treat:
•
high blood pressure
(hypertension)
•
some heart conditions such as
heart failure after a heart attack
•
kidney problems in some patients
Tritace is also used to reduce the risk
of cardiovascular problems and
complications in patients aged 55
years or more with heart or blood
vessel disease, or diabetes.
HYPERTENSION
Tritace is used to lower high blood
pressure (hypertension). Everyone
has blood pressure. This pressure
helps get your blood all around your
body. Your blood pressure may be
different at different times of the day
and can be influenced by how busy
or worried you are. You have
hypertension when your blood
pressure stays higher than is needed,
even when you are calm and relaxed.
There are usually no symptoms of
hypertension. The only way of
knowing that you have hypertension
is to have your blood pressure
checked on a regular basis. If high
blood pressure is not treated it can
lead to serious health problems,
including stroke, heart disease and
kidney failure.
HEART FAILURE AFTER A HEART ATTACK
Tritace may be used after a heart
attack. A heart attack occurs when
one of the major blood vessels
supplying blood to your heart
becomes blocked. This means that
your heart muscle cannot receive the
oxygen it needs and becomes
damaged. This may lead to fu

Đặc tính sản phẩm

Tritace Approved PI 

CCDSv12 PIv18 23 Aug 13
_ _
_Page 1  _

PRODUCT INFORMATION 
TRITACE


NAME OF THE MEDICINE 
NON-PROPRIETARY NAME 
Ramipril 
DESCRIPTION 
Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivative. It is a white, crystalline substance 
soluble  in  polar  organic  solvents  and  buffered  aqueous  solutions.  Ramipril  melts  between  105

C  and 
112

C. 
Ramipril's 
chemical 
name 
is 
(2S,3aS,6aS)-1[(S)-N-[(S)-l-Carboxy-3-phenylpropyl] 
-
alanyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid, 1-ethyl ester; its structural formula
is: 

Its empiric formula is C
23
H
32
N
2
O
5
, and its molecular weight is 416.5. Ramipril has 5 chiral centres. It has 
S-configuration in all 5 asymmetric carbon atoms. 
CAS  87333-19-5 
PHARMACOLOGY  
MECHANISM OF ACTION 
Ramipril is a prodrug which, after  absorption from the gastrointestinal tract, is hydrolysed in the liver to 
form  the  active  moiety,  ramiprilat.  Ramipril  and  ramiprilat  inhibit  angiotensin-converting  enzyme  (ACE) 
which is identical to KININASE II. This converting enzyme (ACE) is a peptidyl dipeptidase that  catalyses 
the  conversion  of  angiotensin  I  to  the  vasoconstrictor  substance,  angiotensin  II.  Angiotensin  II  also 
stimulates  aldosterone  secretion  by  the  adrenal  cortex,  thus  inhibition  of  ACE  results  in  decreased 
plasma  angiotensin  II,  which  leads  to  decreased  vasopressor  activity  and  to  decreased  aldosterone 
secretion. The latter decrease may result in a small increase
in serum potassium. 
KININASE  II  is  one  of  the  enzymes  responsible  for  the  degradation  of  bradykinin,  a  potent 
vasodepressor  peptide.  The  inhibition  of  KININASE  II  a