TRIAMTERENE HYDROCHLOROTHIAZIDE- triamterene and hydrochlorothiazide tablet

Quốc gia: Hoa Kỳ

Ngôn ngữ: Tiếng Anh

Nguồn: NLM (National Library of Medicine)

Thành phần hoạt chất:

TRIAMTERENE (UNII: WS821Z52LQ) (TRIAMTERENE - UNII:WS821Z52LQ), HYDROCHLOROTHIAZIDE (UNII: 0J48LPH2TH) (HYDROCHLOROTHIAZIDE - UNII:0J48LPH2TH)

Sẵn có từ:

BluePoint Laboratories

INN (Tên quốc tế):

TRIAMTERENE

Thành phần:

TRIAMTERENE 37.5 mg

Tuyến hành chính:

ORAL

Loại thuốc theo toa:

PRESCRIPTION DRUG

Chỉ dẫn điều trị:

This fixed combination drug is not indicated for the initial therapy of edema or hypertension except in individuals in whom the development of hypokalemia cannot be risked. Triamterene and hydrochlorothiazide may be used alone or in combination with other antihypertensive drugs such as beta-blockers. Since triamterene and hydrochlorothiazide may enhance the actions of these drugs, dosage adjustments may be necessary. The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia. Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy. Thiazides are indicated in pregnancy when edema is due to pathologic causes, just as they are in absence of pregnancy. Dependent edema in pregnancy, resulting from restriction of venous retur

Tóm tắt sản phẩm:

Triamterene and hydrochlorothiazide tablets, USP for oral administration are available as: 37.5 mg/25 mg: round, green, partial scored tablets, debossed GG 165 on one side and plain on the reverse side and supplied as: NDC 68001-216-00 bottles of 100 NDC 68001-216-03 bottles of 500 75 mg/50 mg: round, yellow, scored tablets, debossed GG 172 on one side and plain on the reverse side and supplied as: NDC 68001-215-00 bottles of 100 NDC 68001-215-03 bottles of 500 Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature]. Protect from light. Dispense in a tight, light-resistant container.

Tình trạng ủy quyền:

Abbreviated New Drug Application

Đặc tính sản phẩm

TRIAMTERENE HYDROCHLOROTHIAZIDE- TRIAMTERENE AND HYDROCHLOROTHIAZIDE
TABLET
BLUEPOINT LABORATORIES
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TRIAMTERENE AND HYDROCHLOROTHIAZIDE TABLETS, USP
DESCRIPTION
Triamterene and hydrochlorothiazide tablets combine triamterene, a
potassium-conserving diuretic with
the natriuretic agent hydrochlorothiazide. Each tablet for oral
administration contains 37.5 mg
triamterene and 25 mg hydrochlorothiazide or 75 mg triamterene and 50
mg hydrochlorothiazide.
Inactive ingredients include croscarmellose sodium, D & C Yellow #10
Aluminum Lake,
hydroxypropyl methylcellulose, magnesium stearate, microcrystalline
cellulose, polysorbate 80, and
sodium bicarbonate. The 37.5 MG/25 MG tablet also contains FD & C Blue
#1 Aluminum Lake.
Triamterene is 2,4,7-triamino-6-phenylpteridine. Triamterene is
practically insoluble in water, benzene,
chloroform, ether and dilute alkali hydroxides. It is soluble in
formic acid and sparingly soluble in
methoxyethanol. Triamterene is very slightly soluble in acetic acid,
alcohol and dilute mineral acids. Its
molecular weight is 253.27. Its structural formula is:
Hydrochlorothiazide is 6-chloro-3,4-dihydro-2_H_-1,2,4,
benzothiadiazine-7-sulfonamide 1, 1-dioxide.
Hydrochlorothiazide is slightly soluble in water and freely soluble in
sodium hydroxide solution, n-
butylamine and dimethylformamide. It is sparingly soluble in methanol
and insoluble in ether,
chloroform and dilute mineral acids. Its molecular weight is 297.73.
Its structural formula is:
CLINICAL PHARMACOLOGY
Triamterene and hydrochlorothiazide is a diuretic, antihypertensive
drug product, principally due to its
hydrochlorothiazide component; the triamterene component reduces the
excessive potassium loss which
may occur with hydrochlorothiazide use.
TRIAMTERENE
Triamterene is a potassium conserving (antikaliuretic) diuretic with
relatively weak natriuretic
properties. It exerts its diuretic effect on the distal renal tubule
to inhibit the reabsorption of sodium in
exchange for potassium and hydrogen. With this action, triamterene