TEVA-TRIMEL DS TABLET

Quốc gia: Canada

Ngôn ngữ: Tiếng Anh

Nguồn: Health Canada

Thành phần hoạt chất:

TRIMETHOPRIM; SULFAMETHOXAZOLE

Sẵn có từ:

TEVA CANADA LIMITED

Mã ATC:

J01EE01

INN (Tên quốc tế):

SULFAMETHOXAZOLE AND TRIMETHOPRIM

Liều dùng:

160MG; 800MG

Dạng dược phẩm:

TABLET

Thành phần:

TRIMETHOPRIM 160MG; SULFAMETHOXAZOLE 800MG

Tuyến hành chính:

ORAL

Các đơn vị trong gói:

100/500

Loại thuốc theo toa:

Prescription

Khu trị liệu:

SULFONAMIDES

Tóm tắt sản phẩm:

Active ingredient group (AIG) number: 0208901003; AHFS:

Tình trạng ủy quyền:

APPROVED

Ngày ủy quyền:

2014-02-07

Đặc tính sản phẩm

PRODUCT MONOGRAPH
Including Patient Medication Information
PR TEVA-TRIMEL TABLETS
PR TEVA-TRIMEL DS TABLETS
sulfamethoxazole and trimethoprim tablets
PR TEVA-TRIMEL ORAL SUSPENSION
sulfamethoxazole and trimethoprim oral suspension
ANTIBACTERIAL AGENT
Teva Canada Limited
DATE OF REVISION:
30 Novopharm Court
February 2, 2018
Toronto, Ontario
Canada M1B 2K9
www.tevacanada.com
Submission Control: 205917
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_TEVA-TRIMEL _
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PRODUCT MONOGRAPH
PR TEVA-TRIMEL TABLETS AND ORAL SUSPENSION
(sulfamethoxazole and trimethoprim)
ANTIBACTERIAL AGENT
CLINICAL PHARMACOLOGY
Teva-Trimel (sulfamethoxazole and trimethoprim) is an antibacterial
agent with a wide spectrum
of activity. It contains two active antibacterial components,
sulfamethoxazole and trimethoprim,
which act synergistically on many species of bacteria.
FIGURE 1
Sulfamethoxazole and trimethoprim act sequentially in two successive
steps in the biosynthesis
of nucleic acids. Trimethoprim is an inhibitor of dihydrofolate
reductase, the enzyme which
reduces dihydrofolic acid to its tetrahydro form. This biochemical
step is essential in the
production of the folate coenzymes which are involved in the
biosynthesis of thymine, purine,
serine and methionine. Sulfamethoxazole exerts its antibacterial
activity by competing with para-
aminobenzoic acid.
Most pathogenic bacteria meet their need for dihydrofolic acid by
synthesizing it from para-
aminobenzoic acid, pteridine and glutamic acid. Animals, in contrast,
depend on exogenous
sources for their needs of folic acid and do not rely upon
intracellular synthesis.
Under usual circumstances, sulfamethoxazole or trimethoprim acting
alone do not produce
complete block in this biosynthesis of nucleic acids. Instead, they
cause sufficient reduction in
the synthesis of folate coenzymes to produce bacteriostasis. When the
two agents act together,
the superimposition of their effects produces a complete block in the
synthesis, leading to death
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of the organism. Thus the effect of the dual