SULFAMETHOXAZOLE AND TRIMETHOPRIM- sulfamethoxazole and trimethoprim tablet

Quốc gia: Hoa Kỳ

Ngôn ngữ: Tiếng Anh

Nguồn: NLM (National Library of Medicine)

Thành phần hoạt chất:

SULFAMETHOXAZOLE (UNII: JE42381TNV) (SULFAMETHOXAZOLE - UNII:JE42381TNV), TRIMETHOPRIM (UNII: AN164J8Y0X) (TRIMETHOPRIM - UNII:AN164J8Y0X)

Sẵn có từ:

Preferred Pharmaceuticals, Inc.

INN (Tên quốc tế):

SULFAMETHOXAZOLE

Thành phần:

SULFAMETHOXAZOLE 800 mg

Tuyến hành chính:

ORAL

Loại thuốc theo toa:

PRESCRIPTION DRUG

Chỉ dẫn điều trị:

To reduce the development of drug-resistant bacteria and maintain the effectiveness of sulfamethoxazole and trimethoprim tablets and other antibacterial drugs, sulfamethoxazole and trimethoprim tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Urinary Tract Infections For the treatment of urinary tract infections due to susceptible strains of the following organisms: Escherichia coli, Klebsiella species , Enterobacter species, Morganella morganii, Proteus mirabilis and Proteus vulgaris . It is recommended that initial episodes of uncomplicated urinary tract infections be treated with a single effective antibacterial agent rather than the combination. Acute Otitis Medi

Tóm tắt sản phẩm:

Sulfamethoxazole and trimethoprim Double Strength tablets (white, scored, oblong), containing 800 mg sulfamethoxazole and 160 mg trimethoprim-bottles of 100 (NDC 61971-120-01) and 500 (NDC 61971-120-05). Imprint on tablets: VP 120. Bottle of 6 - 68788-9500-6 Bottle of 10 - 68788-9500-1 Bottle of 14 - 68788-9500-4 Bottle of 20 - 68788-9500-2 Bottle of 28 – 68788-9500-7 Bottle of 30 - 68788-9500-3 Bottle of 40 - 68788-9500-8 TABLETS SHOULD BE STORED AT 20° TO 25° C (68° to 77°F) ) [see USP Controlled Room Temperature]. DISPENSE IN TIGHT, LIGHT-RESISTANT CONTAINER.

Tình trạng ủy quyền:

Abbreviated New Drug Application

Đặc tính sản phẩm

SULFAMETHOXAZOLE AND TRIMETHOPRIM- SULFAMETHOXAZOLE AND TRIMETHOPRIM
TABLET
PREFERRED PHARMACEUTICALS, INC.
----------
SULFAMETHOXAZOLE AND TRIMETHOPRIM TABLETS, USP
RX ONLY
To reduce the development of drug-resistant bacteria and maintain the
effectiveness of
sulfamethoxazole and trimethoprim tablets and other antibacterial
drugs, sulfamethoxazole and
trimethoprim tablets should be used only to treat or prevent
infections that are proven or strongly
suspected to be caused by bacteria
DESCRIPTION
Sulfamethoxazole and Trimethoprim is a synthetic antibacterial
combination product available in 800 mg
sulfamethoxazole and 160 mg trimethoprim Double Strength tablets and
400 mg sulfamethoxazole and
80 mg trimethoprim tablets for oral administration. Each Double
Strength tablet contains 800 mg
sulfamethoxazole and 160 mg trimethoprim plus magnesium stearate,
pregelatinized starch and sodium
starch glycolate. Each tablet contains 400 mg sulfamethoxazole and 80
mg trimethoprim plus
magnesium stearate, pregelatinized starch, and sodium starch
glycolate. Trimethoprim is 2, 4-diamino-5-
(3,4,5 trimethoxybenzyl) pyrimidine: the molecular formula is C
H N O . It is a white to light
yellow, odorless, bitter compound with a molecular weight of 290.3 and
the following structural
formula:
Sulfamethoxazole is N1-(5-methyl-3-isoxazolyl) sulfanilamide; the
molecular formula is
C10H11N3O3S. It is almost white, odorless, tasteless compound with a
molecular weight of 253.28 and
the following structural formula:
CLINICAL PHARMACOLOGY
Sulfamethoxazole and trimethoprim is rapidly absorbed following oral
administration. Both
sulfamethoxazole and trimethoprim exist in the blood as unbound,
protein-bound and metabolized forms:
sulfamethoxazole also exists as the conjugated form. The metabolism of
sulfamethoxazole occurs
predominately by N4-acetylation, although the glucuronide conjugate
has been identified. The principal
14
18
4
3
metabolites of trimethoprim are the 1- and 3-oxides and the 3'- and
4'-hydroxy derivatives. The free
forms of sul