PLETAL cilostazol 50 mg tablet blister pack

Quốc gia: Úc

Ngôn ngữ: Tiếng Anh

Nguồn: Department of Health (Therapeutic Goods Administration)

Thành phần hoạt chất:

cilostazol

Sẵn có từ:

Otsuka Australia Pharmaceutical Pty Ltd

INN (Tên quốc tế):

Cilostazol

Tình trạng ủy quyền:

Registered

Tờ rơi thông tin

PLETAL
®
_Cilostazol (sil-OS-tah-zol)_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
Please read this leaflet carefully
before you start using PLETAL.
This leaflet answers some common
questions about PLETAL.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking PLETAL
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT PLETAL IS USED
FOR
PLETAL is used to treat intermittent
claudication. Blockage of the blood
vessels to the legs, causes a
distinctive type of pain called
intermittent claudication. In this
condition, which usually affects the
calves, you experience muscle pain
or cramping whenever you walk
some distance, but the pain
disappears when you rest. The pain
occurs because the calf muscles are
not receiving enough oxygen.
PLETAL is only recommended for
patients whose symptoms have not
improved sufficiently after making
life-style modifications (such as
stopping smoking and increasing
exercise) and after other appropriate
interventions. It is important that you
continue the modifications you have
made to your life-style whilst taking
cilostazol.
PLETAL belongs to a group of
medicines called phosphodiesterase
inhibitors.
This medicine works by preventing
blood clots and widening blood
vessels.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY THIS MEDICINE
HAS BEEN PRESCRIBED FOR YOU.
Your doctor may have prescribed it
for another reason.
This medicine is available only with
a doctor’s prescription.
There is not enough information to
recommend the use of this medicine
for children under the age of 18
years.
BEFORE YOU TAKE
PLETAL
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE PLETAL IF YOU HAVE
AN ALLERGY TO:
•
any medicine containing
cilostazol
•
any of the ingredients listed at the
end of

Đặc tính sản phẩm

PRODUCT INFORMATION
PLETAL
®
(CILOSTAZOL)
NAME OF THE MEDICINE
Pletal (cilostazol) is a quinolinone derivative which inhibits
cellular phosphodiesterase (more specific for
phosphodiesterase 3).
Molecular formula
C
20
H
27
N
5
O
2
Molecular wt
369.47
CAS
73963-72-1
The
IUPAC
name
for
cilostazol
is
6-[4-(1-cyclohexyl-1_H-_tetrazol-5-yl)butoxy]-3,4-dihydro-2(1_H_)-
quinolinone.
DESCRIPTION
Cilostazol is slightly soluble in methanol and ethanol and practically
insoluble in water, 0.1N HCl, and
0.1N NaOH.
The tablets are an immediate release formulation containing maize
starch, microcrystalline cellulose,
carmellose calcium, hypromellose and magnesium stearate.
PHARMACOLOGY
PHARMACODYNAMICS
Pharmacotherapeutic group:
Antithrombotic agents, platelet aggregation inhibitor
Animal studies have shown Pletal to have vasodilator effects and this
has been demonstrated in small
studies in man where ankle blood flow was measured by strain gauge
plethysmography. Pletal also
inhibits smooth muscle cell proliferation in rat and human smooth
muscle cells in vitro, and inhibits the
release of platelet-derived growth factor and PF-4 from human
platelets.
Studies in animals (in vivo and ex vivo) have shown that Pletal causes
inhibition of platelet aggregation.
The inhibition is effective against a range of aggregants (including
shear stress, arachidonic acid,
collagen, ADP and adrenaline); in man the inhibition lasts for up to
12 hours, and on cessation of
administration
of
Pletal
recovery
of
aggregation
occurs
within
48-96
hours,
without
rebound
hyperaggregability.
PHARMACOKINETICS
_ABSORPTION: _ Following multiple doses of Pletal 100 mg twice daily
in patients with peripheral vascular
disease, steady state is achieved within 4 days. The Cmax of Pletal
and its two active metabolites
increase less than proportionally with increasing doses.
However, the AUC for Pletal and its metabolites
increase approximately proportionately with dose.
_Pletal (cilostazol 50 mg and 100 mg tablets) _
_Product Information _
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