Quốc gia: Hoa Kỳ
Ngôn ngữ: Tiếng Anh
Nguồn: NLM (National Library of Medicine)
METOPROLOL TARTRATE (UNII: W5S57Y3A5L) (METOPROLOL - UNII:GEB06NHM23)
Novartis Pharmaceuticals Corporation
METOPROLOL TARTRATE
METOPROLOL TARTRATE 5 mg in 5 mL
PRESCRIPTION DRUG
New Drug Application
LOPRESSOR- METOPROLOL TARTRATE INJECTION, SOLUTION NOVARTIS PHARMACEUTICALS CORPORATION ---------- LOPRES S OR METOPROLOL TARTRATE INJECTION, USP RX ONLY PRESCRIBING INFORMATION DESCRIPTION Lopressor, metoprolol tartrate USP, is a selective beta -adrenoreceptor blocking agent, available in 5- mL ampuls for intravenous administration. Each ampul contains a sterile solution of metoprolol tartrate USP, 5 mg, and sodium chloride USP, 45 mg, and water for injection USP. Metoprolol tartrate USP is (±)-1-(Isopropylamino)-3-[_p_-(2-methoxyethyl)phenoxy]-2-propanol L-(+)-tartrate (2:1) salt, and its structural formula is: Metoprolol tartrate USP is a white, practically odorless, crystalline powder with a molecular weight of 684.82. It is very soluble in water; freely soluble in methylene chloride, in chloroform, and in alcohol; slightly soluble in acetone; and insoluble in ether. CLINICAL PHARMACOLOGY MECHANISM OF ACTION Lopressor is a beta -selective (cardioselective) adrenergic receptor blocker. This preferential effect is not absolute, however, and at higher plasma concentrations, Lopressor also inhibits beta - adrenoreceptors, chiefly located in the bronchial and vascular musculature. Clinical pharmacology studies have demonstrated the beta-blocking activity of metoprolol, as shown by (1) reduction in heart rate and cardiac output at rest and upon exercise, (2) reduction of systolic blood pressure upon exercise, (3) inhibition of isoproterenol-induced tachycardia, and (4) reduction of reflex orthostatic tachycardia. _Hypertension_ The mechanism of the antihypertensive effects of beta-blocking agents has not been fully elucidated. However, several possible mechanisms have been proposed: (1) competitive antagonism of catecholamines at peripheral (especially cardiac) adrenergic neuron sites, leading to decreased cardiac output; (2) a central effect leading to reduced sympathetic outflow to the periphery; and (3) suppression of renin activity. _Angina Pectoris_ By blocking catecholamine-induced increases in heart rate, i Đọc toàn bộ tài liệu