Lercadip

Quốc gia: Úc

Ngôn ngữ: Tiếng Anh

Nguồn: Department of Health (Therapeutic Goods Administration)

Thành phần hoạt chất:

Lercanidipine hydrochloride

Sẵn có từ:

Abbott Australasia Pty Ltd

Lớp học:

Medicine Registered

Tờ rơi thông tin

LERCADIP

_Lercanidipine hydrochloride_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some of the
common questions about Lercadip. It
does not contain all the available
information. It does not replace
seeking advice from your doctor or
pharmacist.
PLEASE READ THIS LEAFLET BEFORE YOU
START TAKING LERCADIP.
If you are helping someone else take
Lercadip, please read this leaflet
before you give the first dose.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Lercadip
against the benefits this medicine is
expected to have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT LERCADIP IS USED
FOR
The name of your medicine is
Lercadip, which is also known as
lercanidipine. Lercadip belongs to a
group of medicines called calcium
channel blockers (of the
dihydropyridine group).
Lercadip lowers high blood pressure,
which doctors call hypertension. It
works by relaxing some of the blood
vessels in the body and reducing
resistance to the flow of blood
through the blood vessels.
Everyone has blood pressure. This
pressure helps get your blood all
around your body. Your blood
pressure may be different at different
times of the day, depending on how
busy or worried you are. You have
hypertension (high blood pressure)
when your blood pressure stays
higher than is needed, even when you
are calm and relaxed.
There are usually no symptoms of
hypertension. The only way of
knowing that you have hypertension
is to have your blood pressure
checked on a regular basis. If high
blood pressure is not treated it can
lead to serious health problems. You
may feel fine and have no symptoms,
but eventually hypertension can
cause stroke, heart disease and
kidney failure. Lercadip helps lower
your blood pressure.
Lercadip cannot be obtained without
a doctor's prescription.
There is no evidence that Lercadip is
addictive.
BEFORE YOU TAKE
LERCADIP
_WHEN YOU

Đặc tính sản phẩm

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PRODUCT INFORMATION 
LERCADIP® 
NAME OF THE MEDICINE 
NON-PROPRIETARY NAME 
Lercanidipine hydrochloride 
CHEMICAL STRUCTURE 
Lercanidipine is a dihydropyridine derivative. It is a racemate due to the presence of a 
chiral carbon atom at position 4 of the 1,4-dihydropyridine ring. 

3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,
6-dimethyl-4-(3-nitrophenyl)-2-[(3,3-
diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester hydrochloride.  

MW: 648.2 (free base: 611.7). 
CAS NUMBER 
132866-11-6 
DESCRIPTION 
Lercanidipine hydrochloride is a microcrystalline, odourless, citrine powder, readily 
soluble in chloroform and methanol, practically insoluble
in water. Octanol:water partition 
coefficient (LogP): 6.4.  
Lercadip  tablets also contain the
excipients lactose, microcrystalline cellulose, sodium 
starch glycollate, povidone and magnesium stearate. The tablets are
film-coated with the 
proprietary ingredients Opadry OY-SR-6497 (10
mg-yellow) or Opadry O2-F2-5077 (20 
mg-pink). 
N
C
H
3
CH
3
O
O
O
O
NO
2
H
N
C
H
3
CH
3
CH
3
C
H
3
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PHARMACOLOGY 
PHARMACODYNAMICS 
Lercanidipine is a calcium antagonist of the dihydropyridine group
and selectively inhibits 
the transmembrane influx of calcium into cardiac and
vascular smooth muscle, with a 
greater effect on vascular smooth muscle than on cardiac smooth muscle. The 
antihypertensive action is due to a direct relaxant effect on vascular smooth muscle 
which lowers total peripheral resistance and hence blood pressure.
Lercanidipine has a 
prolonged antihypertensive activity because of its high membrane partition coefficient. It 
is devoid of negative inotropic effects and its vascular selectivity is due to its voltage-
dependent calcium antagonist activity. Since the vasodilatation
induced by le