HYDROCORTISONE tablet

Quốc gia: Hoa Kỳ

Ngôn ngữ: Tiếng Anh

Nguồn: NLM (National Library of Medicine)

Thành phần hoạt chất:

HYDROCORTISONE (UNII: WI4X0X7BPJ) (HYDROCORTISONE - UNII:WI4X0X7BPJ)

Sẵn có từ:

Avera McKennan Hospital

INN (Tên quốc tế):

HYDROCORTISONE

Thành phần:

HYDROCORTISONE 20 mg

Loại thuốc theo toa:

PRESCRIPTION DRUG

Tình trạng ủy quyền:

New Drug Application Authorized Generic

Đặc tính sản phẩm

HYDROCORTISONE- HYDROCORTISONE TABLET
AVERA MCKENNAN HOSPITAL
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HYDROCORTISONE TABLETS, USP
DESCRIPTION
Hydrocortisone tablets contain hydrocortisone which is a
glucocorticoid. Glucocorticoids are
adrenocortical steroids, both naturally occurring and synthetic, which
are readily absorbed from the
gastrointestinal tract. Hydrocortisone USP is white to practically
white, odorless, crystalline powder
with a melting point of about 215° C. It is very slightly soluble in
water and in ether; sparingly soluble
in acetone and in alcohol; slightly soluble in chloroform.
The chemical name for hydrocortisone is
pregn-4-ene-3,20-dione,11,17,21-trihydroxy-, (11β)-. Its
molecular weight is 362.46 and the structural formula is as outlined
below.
Hydrocortisone tablets are available for oral administration in three
strengths: each tablet contains
either 5 mg, 10 mg, or 20 mg of hydrocortisone. Inactive ingredients:
calcium stearate, corn starch,
lactose, mineral oil, sorbic acid, sucrose.
ACTIONS
Naturally occurring glucocorticoids (hydrocortisone and cortisone),
which also have salt-retaining
properties, are used as replacement therapy in adrenocortical
deficiency states. Their synthetic analogs
are primarily used for their potent anti-inflammatory effects in
disorders of many organ systems.
Glucocorticoids cause profound and varied metabolic effects. In
addition, they modify the body's
immune responses to diverse stimuli.
INDICATIONS AND USAGE
Hydrocortisone tablets are indicated in the following conditions.
1. ENDOCRINE DISORDERS
Primary or secondary adrenocortical insufficiency (hydrocortisone or
cortisone is the first choice;
synthetic analogs may be used in conjunction with mineralocorticoids
where applicable; in infancy
mineralocorticoid supplementation is of particular importance)
Congenital adrenal hyperplasia
Non suppurative thyroiditis
Hypercalcemia associated with cancer
2. RHEUMATIC DISORDERS
As adjunctive therapy for short-term administration (to tide the
patient over an acute episode or
exacerbation) in: