hovid-Montelukast Chewable Tablet 4mg

Quốc gia: Malaysia

Ngôn ngữ: Tiếng Anh

Nguồn: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Thành phần hoạt chất:

MONTELUKAST SODIUM

Sẵn có từ:

HOVID BERHAD

INN (Tên quốc tế):

MONTELUKAST SODIUM

Các đơn vị trong gói:

30tablet Tablets; 10tablet Tablets

Sản xuất bởi:

HOVID BERHAD

Tờ rơi thông tin

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
HOVID
-
MONTELUKAST
CHEWABLE
TABLET 4MG
Montelukast (4 mg)
1
WHAT IS IN THIS LEAFLET
1.
What Hovid-Montelukast is used
for
2.
How Hovid-Montelukast works
3.
Before you use Hovid-Montelukast
4.
How to use Hovid-Montelukast
5.
While you are using Hovid-
Montelukast
6.
Side effects
7.
Storage and Disposal of Hovid-
Montelukast
8.
Product description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
11.
Serial Number
WHAT HOVID-MONTELUKAST IS USED FOR
It is used to:
•
prevent and treat asthma in patients
2 to 5 years old
•
relieve day and night symptoms of
seasonal allergic rhinitis (hay fever)
in patients 2 to 5 years old
HOW HOVID-MONTELUKAST WORKS
This medicine is a leukotriene receptor
antagonist. It blocks substances in your
lungs that narrows and swells your
airways. The substance is called
leukotriene.
By blocking leukotrienes, your asthma
symptoms will improve and this helps
prevents asthma attacks. It also
improves hay fever symptoms.
BEFORE YOU USE HOVID-MONTELUKAST
_ _
_- When you must not use it _
Do not take this medicine if:
•
you or your child is allergic to
montelukast
•
you or your child are already
taking any medicine containing
montelukast
•
you or your child is/ are galactose
intolerance, have Lapp lactase
deficiency or glucose-galactose
malabsorption
If you are not sure whether you should
start taking this medicine, talk to your
pharmacist or doctor.
_- Before you start to use it _
Tell your doctor if you are taking or
have recently taken any other
medicines, including medicines
obtained without a prescription, as they
may interact with Hovid-Montelukast.
_ _
Tell your doctor if:
•
you are pregnant or plan to get
pregnant
•
you are breastfeeding or plan to
breastfeed.
_ _
_- Taking other medicines_
Talk to your doctor or pharmacist if
you are taking any other medicines in
any form including any that you buy or
obtained without a prescription from
pharmacy, supermarket or health food
shop.
Some medicines may interf

Đặc tính sản phẩm

DESCRIPTION
Oval, pink mottled uncoated tablet, shallow convex faces, with
"HD" embossed on one face.
COMPOSITION
Montelukast Sodium which is equivalent to Montelukast 4 mg.
ACTIONS AND PHARMACOLOGY
The
cysteinyl
leukotrienes
(LTC
4
,
LTD
4
,
LTE
4
)
are
potent
inflammatory eicosanoids released from various cells including
mast
cells
and
eosinophils.
These
important
pro-asthmatic
mediators bind to cysteinyl leukotriene (CysLT) receptors. The
CysLT type-1 (CysLT
1
) receptor is found in the human airway
(including airway smooth muscle cells and airway macrophages)
and on other pro-inflammatory cells (including eosinophils and
certain myeloid stem cells). CysLTs have been correlated with the
pathophysiology
of
asthma
and
allergic
rhinitis.
In
asthma,
leukotriene-mediated effects include bronchoconstriction, mucous
secretion, vascular permeability, and eosinophil recruitment. In
allergic rhinitis, CysLTs are released from the nasal mucosa after
allergen exposure during both early- and late-phase reactions and
are
associated
with
symptoms
of
allergic
rhinitis.
Intranasal
challenge with CysLTs has been shown to increase nasal airway
resistance and symptoms of nasal obstruction.
Montelukast is a potent, orally active compound that significantly
improves
parameters
of
asthmatic
inflammation.
Based
on
biochemical and pharmacological bioassays, it binds with high
affinity and selectivity to the CysLT
1
receptor (in preference to
other pharmacologically important airway receptors such as the
prostanoid, cholinergic, or ß-adrenergic receptor). Montelukast
potently inhibits physiologic actions of LTC
4
, LTD
4
and LTE
4
at the
CysLT
1
receptor without any agonist activity.
PHARMACOKINETICS
ABSORPTION:
Montelukast is rapidly absorbed following oral administration. After
administration of the 4 mg chewable tablet to paediatric patients 2
to 5 years of age in the fasted state, Cmax is achieved 2 hours
after administration. The mean Cmax is 66% higher while mean
Cmin is lower than in adults receiving a 10 mg tablet.
DISTRIBUTIO