Fluothane (Halothane Inhalation Liquid 100% vv)

Quốc gia: Malaysia

Ngôn ngữ: Tiếng Anh

Nguồn: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Thành phần hoạt chất:

HALOTHANE

Sẵn có từ:

UNIMED SDN BHD

INN (Tên quốc tế):

HALOTHANE

Các đơn vị trong gói:

250ml mL

Sản xuất bởi:

Piramal Pharma Limited

Tờ rơi thông tin

Not Applicable

Đặc tính sản phẩm

outside hospital.
WARNING AND PRECAUTION
Halothane can induce liver damage. Minor changes
in
serum
amino-transferase
activity
have
been
reported to occur in up to 30% of patients. The
incidence of severe liver damage (jaundice, which
may lead to hepatic failure as a consequence of
massive hepatic cell necrosis) is much rarer but
cases requiring liver transplants and fatalities have
been reported. The risk of developing hepatic failure
appears
to
be
greatly
incrased
by
repeated
exposure to halothane. Although short intervals of
time between exposures are likely to increase the
risk of hepatoxicity, even long intervals between
exposure may not reduce the risks, since some
patients
have
developed
severe
reactions
to
halothane given many years after the previous
exposure.
Other
risk
factors
for
hepatotoxcity
include female gender, obesity, middle age and a
history
of
drug
allergy
on
present
available
information, the following precautions should be
taken:
1.A careful anesthetic history is to be taken from
patients due to undergo anesthesia in order to
determine whether exposure to halothane took
place and the nature of any adverse reaction to
this agent.
2.History of unexplained jaundicie or pyrexia after a
previous exposure to halothane is an absolute
contraindication to its future use in that patient.
3.Further
exposure
to
Halothane
within
three
months
is
to
be
avoided
unless
there
are
overriding reasons for its re-use.
4.Patients who have exhibited adverse reactions to
halothane
should
be
informed
and
strictly
instructed to alert their Physician. Details of the
reaction
should
be
entered
on
the
patient's
medical records.
A rise in CSF and / or intracranial pressure might
occur during neurosurgery, the effects of which may
be mitigated by the use moderate hyperventilation.
Halothane
reduces
uterine
muscle
tone
during
pregnancy and generally its use is not recommended
in
obstetrics
because
of
the
increased
risk
of
postpartum
haemorrhage.
Halothane
should
be
used with caution in patients with:
• Phaeochromocytoma
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