FEPRIL TABLET 500MG

Quốc gia: Malaysia

Ngôn ngữ: Tiếng Anh

Nguồn: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Thành phần hoạt chất:

Paracetamol

Sẵn có từ:

IDAMAN PHARMA MANUFACTURING SDN BHD

INN (Tên quốc tế):

Paracetamol

Các đơn vị trong gói:

1000 Tablets; 100 Tablets

Sản xuất bởi:

IDAMAN PHARMA MANUFACTURING SDN BHD

Tờ rơi thông tin

FEPRIL TABLET 500MG
Paracetamol (500mg)
1
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
WHAT IS IN THIS LEAFLET
1.
What FEPRIL is used for
2.
How FEPRIL works
3.
Before you use FEPRIL
4.
How to use FEPRIL
5.
While you are using FEPRIL
6.
Side effects
7.
Storage and disposal of FEPRIL
8.
Product description
9.
Product
Registration
Holder
&
Manufacturer
10.
Date of revision
WHAT FEPRIL IS USED FOR
FEPRIL
is
used
for
relief
of
mild
to
moderate
pain
and
to
reduce
fever.
It
provides
symptomatic
relief
only;
additional therapy to treat the cause of
the
pain
or
fever
should
be
instituted
when necessary.
HOW FEPRIL WORKS
FEPRIL has analgesic (pain relief) and
antipyretic (anti-fever) properties.
BEFORE YOU USE FEPRIL
-
_When you must not use it _
Do not take FEPRIL if you are allergic to
Paracetamol or Acetaminophen.
Do not take FEPRIL if you are pregnant,
trying to get pregnant or think you may
be pregnant without discussing with your
doctor first.
Do not take FEPRIL if you are breast-
feeding.
If you are not sure whether you should
start taking this medicine, talk to your
doctor or pharmacist.
-
_Before you start to use it _
Tell your doctor if you have allergies to
Paracetamol or Acetaminophen.
Your doctor needs to know before you
take FEPRIL if you have kidney or liver
problem. FEPRIL should be given with
care to patients with impaired kidney or
liver function.
FEPRIL should also be
given with care to patients taking other
drugs that affect the liver.
Your doctor needs to know if you are
intolerant of aspirin. Patient intolerant of
aspirin may not be intolerant of FEPRIL,
however
mild
bronchospastic
reactions
with FEPRIL have been reported in some
aspirin-sensitive asthmatics.
Discuss with your doctor or pharmacist
first if you are pregnant or breastfeeding.
-
_Taking other medicines _
Tell
your
doctor
or
pharmacist
before
taking
FEPRIL,
if
you
are
taking
any
other medicines, including any that you
buy
without
a
prescription
from
pharmacy,
supermarket
or
health
food
shop. The effects of some medicines may
be affe

Đặc tính sản phẩm

IDAMAN PHARMA MANUFACTURING
FEPRIL TABLET 500MG
PRODUCT DESCRIPTION
Round and biconvex tablets with one side scored. White to off white in
colour.
Each tablet contains: Paracetamol 500mg
_Preservative:- _
Potassium Sorbate: 0.58mg
ROUTE OF ADMINISTRATION
Oral
PHARMACODYNAMICS
Paracetamol is a centrally acting analgesic and antipyretic with
minimal
anti-inflammatory properties.
Analgesic
The mechanism of analgesic action has not been fully determined.
Paracetamol
may
act
predominantly
by
inhibiting
prostaglandin
synthesis in the central nervous system (specifically cyclooxygenase
(COX)-2) and, to a lesser extent, through a peripheral action by
blocking
pain impulse generation.
The peripheral action may also be due to inhibition of prostaglandin
synthesis or to inhibition of the synthesis or actions of other
substances
that sensitize pain receptors to mechanical or chemical stimulation.
Antipyretic
Paracetamol act centrally on the hypothalamic heat-regulating center
to produce peripheral vasodilatation resulting in increased blood flow
through the skin, sweating and heat loss.
Paracetamol reduces fever by inhibiting the formulation and release of
prostaglandins in the CNS and by inhibiting endogenous pyrogens at the
hypothalamic thermoregulator center.
PHARMACOKINETICS
Absorption
After oral administration Paracetamol is rapidly and almost completely
absorbed. Peak plasma concentrations are reached after 30 minutes to
2 hours.
Distribution
Paracetamol
is
distributed
rapidly
throughout
all
tissues.
Concentrations are comparable in blood, saliva and plasma.
The volume of distribution of Paracetamol is approximately 1 L/kg
bodyweight. At therapeutic doses protein binding is negligible.
Metabolism
In adults, paracetamol is conjugated in the liver with glucuronic acid
(~60%),
sulphate
(~35%)
conjugates.
The
latter
route
is
rapidly
saturated at doses higher than the therapeutic dose. A minor route,
catalyzed by the cytochrome P450, results in the formation of an
intermediate reagent (N acetyl-p-benzoquinoneimine) which un