Quốc gia: Malaysia
Ngôn ngữ: Tiếng Anh
Nguồn: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Irbesartan
PHARMANIAGA MANUFACTURING BERHAD
Irbesartan
30 Tablets; 30 Tablets
PHARMANIAGA MANUFACTURING BERHAD
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ CRUZOR TABLET Irbesartan (150mg, 300mg) _ _ 1 WHAT IS IN THIS LEAFLET 1. What Cruzor Tablet is used for 2. How Cruzor Tablet works 3. Before you use Cruzor Tablet 4. How to use Cruzor Tablet 5. While you are using Cruzor Tablet 6. Side effects 7. Storage and disposal of Cruzor Tablet 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of Revision WHAT CRUZOR TABLET IS USED FOR Cruzor tablet is used to treat high blood pressure (essential hypertension) and to protect the kidney in patients with high blood pressure, type 2 diabetes with laboratory evidence of impaired kidney function. HOW CRUZOR TABLET WORKS Cruzor tablet _ _ contains Irbesartan as the active ingredient. Irbesartan belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin- II is a substance produced in the body which binds to receptors in blood vessels causing them to tighten. This resulting in an increase in blood pressure. Irbesartan prevents the binding of angiotensin-II to these receptors, causing the blood vessels to relax and the blood pressure to lower. Irbesartan slows the decrease of kidney function in high blood pressure patients with type 2 diabetes. BEFORE YOU USE CRUZOR TABLET _-When you must not use it_ Do not take Cruzor tablet if you: - • have an allergy to Irbesartan or any of the ingredients listed at the end of this leaflet. • are more than 3 months pregnant. (It is also better to avoid taking Irbesartan in early pregnancy) • are breast-feeding. If you are not sure whether you should start taking this medicine, do consult your doctor. _-Before you start to use it_ Cruzor Tablet contains lactose. If you have been told by your doctor that you have lactose intolerance, consult your doctor before taking this medicine. _-Taking other medicines _ Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop. Some medicines and Cr Đọc toàn bộ tài liệu
CRUZOR I R B E S A R T A N CRUZORTABLET 300 MG CRUZOR TABLET 150 MG COMPOSITION CRUZOR TABLET 150MG Each film coated tablet contains 150mg of Irbesartan CRUZOR TABLET 300MG Each film coated tablet contains 300mg of Irbesartan DESCRIPTION CRUZOR TABLET 150MG 12.5 mm length, white to off-white, oval-shaped film-coated tablet with Pharmaniaga icon on one side and plain on the other side. CRUZOR TABLET 300MG 15.5 mm length, white to off-white, oval-shaped film-coated tablet with Pharmaniaga icon on one side and plain on the other side. PHARMACODYNAMICS Irbesartan is a potent, orally active, selective angiotensin II receptor (type AT 1) antagonist that blocks the binding of angiotensin II to the AT 1 receptor. In the renin-angiotensin system, angiotensin I is converted by angiotensin-converting enzyme (ACE) to form angiotensin II. Angiotensin II stimulates the adrenal cortex to synthesize and secrete aldosterone, which decreases the excretion of sodium and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth muscle. Irbesartan, by blocking the binding of angiotensin II to the AT 1 receptor, promotes vasodilation and decreases the effects of aldosterone. The negative feedback regulation of angiotensin II on renin secretion also is inhibited, but the resulting rise in plasma renin concentrations and consequent rise in angiotensin II plasma concentrations do not counteract the blood pressure–lowering effect that occurs. Irbesartan does not inhibit ACE (kinase II), an enzyme which generates angiotensin II and also degrades bradykinin into inactive metabolites. Irbesartan does not require metabolic activation for its activity. PHARMACOKINETICS ABSORPTION AND DISTRIBUTION After oral administration, irbesartan is well absorbed: studies of absolute bioavailability gave values of approximately 60-80%. Concomitant food intake does not significantly influence the bioavailability of irbesartan. Plasma protein binding is approximately 96%, with negligible binding to cellular bloo Đọc toàn bộ tài liệu