CHLORZOXAZONE tablet

Quốc gia: Hoa Kỳ

Ngôn ngữ: Tiếng Anh

Nguồn: NLM (National Library of Medicine)

Thành phần hoạt chất:

CHLORZOXAZONE (UNII: H0DE420U8G) (CHLORZOXAZONE - UNII:H0DE420U8G)

Sẵn có từ:

Proficient Rx LP

INN (Tên quốc tế):

CHLORZOXAZONE

Thành phần:

CHLORZOXAZONE 500 mg

Tuyến hành chính:

ORAL

Loại thuốc theo toa:

PRESCRIPTION DRUG

Chỉ dẫn điều trị:

Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Chlorzoxazone does not directly relax tense skeletal muscles in man.   Chlorzoxazone is contraindicated in patients with known intolerance to the drug.   

Tóm tắt sản phẩm:

Chlorzoxazone tablets, USP are available as oblong, scored, white tablets debossed with WPI on one side and "39"-"68" on the other side and are packaged in bottles of 20, 30, 60 and 90. Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Dispense contents with a child-resistant closure (as required) and in a tight container as defined in the USP/NF. Keep out of the reach of children. Manufactured By: Watson Pharma Private Limited Verna, Salcette Goa 403 722 INDIA Distributed By: Watson Pharma, Inc. Corona, CA 92880 USA Revised: November 2010                                                                           195609   Repackaged by: Proficient Rx LP Thousand Oaks, CA 91320

Tình trạng ủy quyền:

Abbreviated New Drug Application

Đặc tính sản phẩm

CHLORZOXAZONE- CHLORZOXAZONE TABLET
PROFICIENT RX LP
----------
CHLORZOXAZONE TABLETS, USP 500 MG
REVISED: NOVEMBER 2010
RX ONLY
195609
DESCRIPTION
Chlorzoxazone USP is a centrally acting skeletal muscle relaxant,
available as tablets of
500 mg for oral administration. Its chemical name is
5-Chloro-2-benzoxazolinone, and its
structural formula is:
CHLORZOXAZONE STRUCTURAL FORMULA
Chlorzoxazone Structural Formula
Chlorzoxazone Structural Formula
C H CINO MW 169.57
Chlorzoxazone USP is a white or practically white, practically
odorless, crystalline
powder. Chlorzoxazone is slightly soluble in water; sparingly soluble
in alcohol, in
isopropyl alcohol, and in methanol; soluble in solutions of alkali
hydroxides and ammonia.
Chlorzoxazone tablets contain the inactive ingredients Docusate
Sodium, Lactose
(hydrous), Magnesium Stearate, Microcrystalline Cellulose,
Pregelatinized Starch, Sodium
Benzoate, and Sodium Starch Glycolate.
CLINICAL PHARMACOLOGY
Chlorzoxazone is a centrally-acting agent for painful musculoskeletal
conditions. Data
available from animal experiments as well as human study indicate that
chlorzoxazone
acts primarily at the level of the spinal cord and subcortical areas
of the brain where it
inhibits multisynaptic reflex arcs involved in producing and
maintaining skeletal muscle
spasm of varied etiology. The clinical result is a reduction of the
skeletal muscle spasm
with relief of pain and increased mobility of the involved muscles.
Blood levels of
chlorzoxazone can be detected in people during the first 30 minutes
and peak levels
may be reached, in the majority of the subjects, in about 1 to 2 hours
after oral
administration of chlorzoxazone. Chlorzoxazone is rapidly metabolized
and is excreted
in the urine, primarily in a conjugated form as the glucuronide. Less
than one percent of
a dose of chlorzoxazone is excreted unchanged in the urine in 24
hours.
7
4
2
INDICATIONS AND USAGE
Chlorzoxazone is indicated as an adjunct to rest, physical therapy,
and other measures
for the relief of discomfort assoc