Quốc gia: Malaysia
Ngôn ngữ: Tiếng Anh
Nguồn: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
CEFUROXIME AXETIL
DKSH MALAYSIA SDN BHD
CEFUROXIME AXETIL
2x5'stablet Tablets
PYMEPHARCO
_Consumer Medication Information Leaflet (RiMUP) _ CEFUROXIM STADA FILM COATED CAPLET Cefuroxime axetil (250mg, 500mg) 1 WHAT IS IN LEAFLET 1. What Cefuroxim STADA is used for 2. How Cefuroxim STADA works 3. Before you use Cefuroxim STADA 4. How to use Cefuroxim STADA 5. While you are using it 6. Side effects 7. Storage and Disposal of Cefuroxim STADA 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT CEFUROXIM STADA IS USED FOR Your doctor has chosen this medicine to suit you and your condition. Your doctor has prescribed this medicine because you have an infection on: • Lower respiratory tract infections: pneumonia, acute bronchitis, and acute exacerbations of chronic bronchitis. • Upper respiratory tract infections: ear, nose and throat infections, such as otitis media, sinusitis, tonsillitis, pharyngitis. • Genito-urinary tract infections: pyelonephritis, cystitis and urethritis. • Skin and soft tissue infections: furunculosis, pyoderma, impetigo. • Gonorrhoea, acute uncomplicated gonococcal urethritis, and cervicitis. HOW CEFUROXIM STADA WORKS Cefuroxime axetil which is found Cefuroxim STADA belongs to a group of medicines called cephalosporins which is a type of antibiotic. Antibiotics kill bacteria or “germs” which cause infections. BEFORE YOU USE CEFUROXIM STADA - _When you must not use it _ Do not take Cefuroxim STADA if you have ever had a severe allergenic reaction to an antibiotic known as cephalosporin or any of the ingredients in Cefuroxim STADA. Ask your doctor or pharmacist if you are not sure. - _Before you start to use it _ Tell your doctor about all your medical conditions, including if you: • have experienced an allergic reaction to penicillins or other beta- lactams; • have kidney failure; • have severe gastrointestinal disease; • are in pregnancy • or you are breast feeding a baby because cefuroxime is found in human milk. - _Taking other medicines _ Please tell your doctor or pharmacist if you taking or have recently take Đọc toàn bộ tài liệu
CEFUROXIM STADA 250MG FILM COATED CAPLET COMPOSITION Active Ingredient: Each film coated caplet contains cefuroxime axetil equivalent to 250mg of cefuroxime Other Ingredients: Microcrystalline cellulose, maize starch, crocarmellose sodium, magnesium stearate, talc, hypromellose, polyethylene glycol, titanium dioxide. PHARMACODYNAMIC PROPERTIES The in vivo bactericidal activity of cefuroxime axetil is due to cefuroxime’s binding to essential target proteins and the resultant inhibition of cell-wall synthesis. Cefuroxime has bactericidal activity against a wide range of common pathogens, including many beta-lactamase- producing strains. Cefuroxime is stable to many bacterial beta-lactamases, especially plasmid-mediated enzymes that are commonly found in enterobacteriaceae. Cefuroxime has been demonstrated to be active against most strains of the following microorganisms both in vitro and in clinical infections. AEROBIC GRAM-POSITIVE MICROORGANISMS: _Staphylococcus _ _aureus_ (including beta-lactamase- producing strains), _Streptococcus _ _pneumonia_, _Streptococcus pyogenes_. AEROBIC GRAM-NEGATIVE MICROORGANISMS: _Escherichia coli_, _ Haemophilus influenza_ (including beta- lactamase-producing strains), _Haemophilus parainfluenzae_, _Klebsiella _ _pneumoniae_, _Moraxella _ _catarrhalis_ (including beta-lactamase-producing strains), _ Neisseria gonorrhoeae_ (including beta-lactamase-producing strains) SPIROCHETES: _Borrelia burgdorferi_ PHARMACOKINETIC PROPERTIES ABSORPTION AND METABOLISM: After oral administration, cefuroxime axetil is absorbed from the gastrointestinal tract and rapidly hydrolyzed by nonspecific esterases in the intestinal mucosa and blood to cefuroxime. Absorption of the tablet is greater when taken after food (absolute bioavailability of cefuroxime tablets increases from 37% to 52%). Cefuroxime is not metabolized. Distribution: Cefuroxime is subsequently distributed throughout the extracellular fluids. The axetil moiety is metabolized to acetaldehyde and acetic acid. Approximately 50% of serum Đọc toàn bộ tài liệu