Quốc gia: Malaysia
Ngôn ngữ: Tiếng Anh
Nguồn: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
AMLODIPINE BESILATE
CIPLA MALAYSIA SDN BHD
AMLODIPINE BESILATE
10 X 10 Tablets
CIPLA LTD
AMLOPRES CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) AMLODIPINE BESYLATE USP 5 MG & 10 MG TABLETS __________________________________________________________________________________ 1 WHAT IS IN THIS LEAFLET 1. What AMLOPRES is used for 2. How AMLOPRES works 3. Before you use AMLOPRES 4. How to use AMLOPRES 5. While you are using AMLOPRES 6. Side effects 7. Storage and Disposal of AMLOPRES 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of Revision WHAT AMLOPRES IS USED FOR AMLORPES is used to treat high blood pressure (hypertension) or a certain type of chest pain called angina, a rare form of which is Prinzmetal’s or variant angina. HOW AMLOPRES WORKS Amlodipine is one of a group of medicines called calcium antagonists. In patients with high blood pressure your medicine works by relaxing blood vessels, so that blood passes through them more easily. In patients with angina amlodipine works by improving blood supply to the heart muscle which then receives more oxygen and as a result chest pain is prevented. Your medicine does not provide immediate relief of chest pain from angina. BEFORE YOU USE AMLOPRES _- When you must not use it _ • if you are allergic (hypersensitive) to Amlodipine, or any of the other ingredients of your medicine, or to any other calcium antagonists. This may be itching, reddening of the skin or difficulty in breathing. • if you have narrowing of the aortic heart valve (aortic stenosis), unstable angina or cardiogenic shock; • If you are pregnant or breast feeding. _- Before you start to use it _ You should inform your Doctor if you have or have had any of the following conditions: • Recent heart attack Heart failure • Severe increase in blood pressure (Hypertensive crisis). • Liver disease. • You are elderly and your dose needs to be increased PREGNANCY The safety of AMLOPRES in human pregnancy has not been established. If you think you might be pregnant, or are planning to get pregnant, tell your doctor before you take AMLOPRES. Women of c Đọc toàn bộ tài liệu
CIPLA _FOR THE USE OF A REGISTERED MEDICAL PRACTITIONER OR A HOSPITAL OR A LABORATORY ONLY _ AMLOPRES-5 (AMLODIPINE BESYLATE TABLETS USP 5MG) COMPOSITION Each uncoated tablet contains: Amlodipine Besylate USP equivalent to Amlodipine………..5mg DOSAGE FORM Tablets DESCRIPTION White to off white round tablets with ‘’5’’ debossed on one side and plain on other side. PHARMACOLOGY _PHARMACODYNAMICS _ Amlodipine is a calcium ion influx inhibitor of the dihydropyridine group (slow channel blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle. The mechanism of the antihypertensive action of amlodipine is due to a direct relaxant effect on vascular smooth muscle. The precise mechanism by which amlodipine relieves angina has not been fully determined but amlodipine reduces total ischaemic burden by the following two actions. 1) Amlodipine dilates peripheral arterioles and thus, reduces the total peripheral resistance (afterload) against which the heart works. Since the heart rate remains stable, this unloading of the heart reduces myocardial energy consumption and oxygen requirements. 2) The mechanism of action of amlodipine also probably involves dilatation of the main coronary arteries and coronary arterioles, both in normal and ischaemic regions. This dilatation increases myocardial oxygen delivery in patients with coronary artery spasm (Prinzmetal's or variant angina). CIPLA Amlodipine provides significant 24 hour blood pressure reduction in hypertensive patients. Due to the slow onset of action, acute hypotension is not a feature of amlodipine administration. Amlodipine has been shown to increase exercise time, time to angina onset, and time to 1 mm ST segment depression, and decrease both angina attack frequency and glyceryl trinitrate tablet consumption in patients with angina. Amlodipine has not been associated with any adverse metabolic effects or changes in plasma lipids and is suitable for use in patients with asthma, diabetes Đọc toàn bộ tài liệu