YSP Allopurinol Tablet 100mg

Страна: Малайзія

мова: англійська

Джерело: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Активний інгредієнт:

ALLOPURINOL

Доступна з:

Y.S.P. INDUSTRIES (M) SDN BHD

ІПН (Міжнародна Ім'я):

ALLOPURINOL

Одиниць в упаковці:

100Tablet Tablets; 200Tablet Tablets; 100 Tablet Tablets; 1000 Tablet Tablets; 1000 Tablets

Виробник:

Y.S.P. INDUSTRIES (M) SDN BHD

інформаційний буклет

YSP ALLOPURINOL TABLET
Allopurinol (100mg, 300mg)
1
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
WHAT IS IN THIS LEAFLET
1.
What
YSP
ALLOPURINOL
TABLET is used for
2.
How
YSP
ALLOPURINOL
TABLET works
3.
Before
you
use
YSP
ALLOPURINOL TABLET
4.
How to use YSP ALLOPURINOL
TABLET
5.
While you are using it
6.
Side effects
7.
Storage
and
Disposal
of
YSP
ALLOPURINOL TABLET
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT YSP ALLOPURINOL TABLET
IS USED FOR
It
is
used
to
prevent
gout
attack
and
reduce the formation of excessive uric
acid levels. However, it is not used to
treat established attacks of gout.
HOW YSP ALLOPURINOL TABLET
WORKS
Allopurinol
is
a
xanthine-oxidase
inhibitor
agent
which
reduces
the
formation of excessive uric acid.
BEFORE YOU USE YSP ALLOPURINOL
TABLET
-
_When you must not use it _
Do not take this medicine if:
•
you are allergic to allopurinol or
any other ingredients of this
medicine
(listed
in
Product
Description)
_ _
-
_Before you start to use it _
_Pregnancy and lactation _
Please consult your doctor or pharmacist
if
you
are
pregnant,
planning
for
pregnancy or breast-feeding before using
any medicine.
-
_Taking other medicines _
Tell your doctor if you are taking any
other medicines, including any that you
buy
without
a
prescription
from
a
pharmacy,
supermarket
or
health
food
shop.
HOW
TO
USE
YSP
ALLOPURINOL
TABLET
-
_How much to use _
The recommended dose for adult is to
start
with
100
mg
once
daily.
The
following
dosage
schedules
are
suggested: 100 to 200 mg daily in mild
conditions,
300
to
600
mg
daily
in
moderately severe conditions 700 to 900
mg daily in severe conditions.
If the daily dosage exceeds 300 mg and
develop
gastrointestinal
intolerance,
a
divided
doses
regimen
may
be
appropriate.
Follow all directions given to you by your
doctor
and
pharmacist
carefully.
They
may
differ
from
the
information
contained in this leaflet. If you do not
understand the instructions on the label,
ask your doctor or pharmacist for help.
-
_When to

Характеристики продукта

ATTACHMENT 2
204187 - 05 draft 27 Apr 16 260 X 110
204187 - 05 draft 27 Apr 16 260 X 110
Concurrent use of Allopurinol with captopril may result in increased
risk of toxicity,
especially in renal impairment.
Allopurinol may possibly enhance effects of anticoagulants such as
nicoumalone and
warfarin.
Plasma-cyclosporin
concentration
possibly
increased
by Allopurinol
and
results
in
increased risk of nephrotoxicity.
The plasma half-life of adenine arabinoside is increased in the
presence of allopurinol.
When two products are used concomitantly,extra vigilance is necessary
to recognise
enhanced toxic effects.
Oxipurinol,
the
major
metabolites
of
allopurinol
and
itself
therapeutically
active,
is
excreted by the kidney in a similar way to urate. Hence, drugs with
uricosuric activity,
eg. probenecid or large doses of salicylates may accelerate the
excretion of oxipurinol.
This may decrease the therapeutic activity of allopurinol, but the
significance needs to
be assessed in each case.
If allopurinol is given concomitantly with chlorpropamide when renal
function is poor,
there may be an increased risk of prolonged hypoglycaemic activity.
Allopurinol may inhibit hepatic oxidation of phenytoin, but the
clinical significance has
not been demonstrated.
ATTACHMENT 1
YSP ALLOPURINOL
TABLET
Allopurinol presents a new approach to the therapy of hyperuricemia
associated with gout
and other conditions. It is a potent xanthine oxidase inhibitor with
the chemical formula
4-hydroxypyrazole (3,4-d) pyrimidine (HPP).
INGREDIENT(S):
Allopurinol Tablet :
Each tablet contains:
Allopurinol
…………………......…………………..........…………..................…............
100 mg
Allopurinol Tablet 300mg :
Each tablet contains:
Allopurinol
……………………......………………..........……………..........…..............…300
mg
PHARMACODYNAMICS:
a)
b)
c)
d)
PHARMACOKINETICS:
t1/2 = 18 ~ 30 hours. Metabolized by the liver and eliminated as
Alloxanthine (Oxipurinol) by
renal.
INDICATIONS:
Allopurinol is