TRISEQUENS

Страна: Австралія

мова: англійська

Джерело: Department of Health (Therapeutic Goods Administration)

Активний інгредієнт:

Oestradiol hemihydrate; Norethisterone acetate

Доступна з:

Novo Nordisk Pharmaceuticals Pty Ltd

Клас:

Medicine Registered

Характеристики продукта

Product Information 
Tripi8.doc 

Page 1 of 16 

PRODUCT INFORMATION

TRISEQUENS
® 

NAME OF THE MEDICINE 

Oestradiol  (as hemihydrate) 
Norethisterone acetate  

 DESCRIPTION 

Trisequens is a sequential oestrogen/progestogen preparation
formulated with the natural 
human oestrogen, oestradiol, and norethisterone acetate.  The first
12 tablets in the calendar 
dial pack contain oestradiol alone.  In the next 10 tablets
norethisterone acetate is added to 
induce endometrial shedding.  The last 6 tablets contain a low dose
of oestradiol.  This 
regimen provides adequate oestrogen replacement throughout the cycle
and reduces the risk 
of endometrial hyperplasia. 

ACTIVE INGREDIENTS  
Oestradiol - chemical name: estra-1,3,5(10)-triene-3,17β-diol (as
hemihydrate). Oestradiol is 
a white or almost white crystalline powder which is practically
insoluble in water and soluble 
in acetone.  Oestradiol has 5 chiral centres.  The molecular formula
is C
18
H
24
O
2
. Oestradiol 
hemihydrate has a molecular weight of 281.39. 

Norethisterone acetate - chemical name: 17
-acetoxy-19-nor-17-pregn-4-en-20-yn-3-one. 
Norethisterone acetate (NETA) is a white or yellowish-white
crystalline powder which is 
practically insoluble in water and soluble in ethanol and acetone.
 Norethisterone acetate has 
6 chiral centres.  The molecular formula is C
22
H
28
O
3
, with a molecular weight of 340.5.

STRUCTURE 
Oestradiol hemihydrate 
Norethisterone acetate 

CAS no.: 35380-71-3 
CAS no. 51-98-9 

EXCIPIENTS 
The tablet cores of the blue, white and red tablets contain: lactose,
maize starch, 
hydroxypropylcellulose, talc, magnesium stearate.  

_Film-coatings _
Blue tablets: hypromellose, talc, titanium dioxide (E171), indigo
carmine (E132) and 
macrogol 400. 
’½H
2
O’ 
Product Information 
Tripi8.doc 

Page 2 of 16 

White tablets: hypromellose, glycerol triacetate and talc. 
Red tablets: hypromellose, talc, titanium dioxide (E171), r