Страна: Малайзія
мова: англійська
Джерело: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
AMOXICILLIN TRIHYDRATE; POTASSIUM CLAVULANATE
Thye Pharma Sdn. Bhd
AMOXICILLIN TRIHYDRATE; POTASSIUM CLAVULANATE
100 gm; 1 kg
Thye Pharma Sdn. Bhd
Veterinary Package Insert TP-AMOCLAVU 500/125 MG/G WATER SOLUBLE POWDER PRODUCT DESCRIPTION White, off-white to slightly yellow colour powder, which contains 574mg of amoxicillin trihydrate (500mg of amoxicillin) and 149mg of clavulanate potassium (125mg of clavulanic acid) per gram in sachet. PHARMACODYNAMICS & PHARMACOKINETICS The product is a combination of a beta-lactam antibiotic with a beta-lactamase inhibitor which restores the potency of amoxicillin against strains producing beta-lactamases. Amoxicillin is a bactericidal antibiotic, which acts by inhibiting the synthesis of bacterial cell wall during bacterial multiplication. It inhibits cross-linkage between the linear peptidoglycan polymer chains in the cell wall of Gram-positive bacteria. Broad- spectrum penicillin antibiotic amoxicillin is active also against a limited range of Gram-negative bacteria where the outer layer of bacterial cell wall is made up of lipopolysaccharide and protein. There are three principal mechanisms of resistance to beta-lactam antibiotics: production of beta- lactamases, alteration of the PBP (Penicillin- binding proteins), diminished outer membrane permeation. One of the most important is inactivation of penicillin antibiotics by beta- lactamase enzymes produced by certain bacteria. These enzymes cleave the penicillin beta-lactam ring and render the penicillin drug inactive. Clavulanic acid acts as inhibitor of bacterial beta- lactamases. It prevents destruction of the beta- lactam ring and penicillins by beta-lactamase enzymes. The reaction is irreversible and both the enzyme and the clavulanate are destroyed while the antibiotic activity is preserved. The role of the clavulanic acid in the combination is not only to act as a beta-lactamase inhibitor. Clinical efficacy is dependent upon a number of factors including not only intrinsic antibacterial properties but also a positive interaction with host defenses. After exposure to an antibacterial compound, the resulting alteration of cell wall integrity and changes in bacte Прочитайте повний документ