THYROID TABLET

Страна: Канада

мова: англійська

Джерело: Health Canada

Активний інгредієнт:

THYROID

Доступна з:

SEARCHLIGHT PHARMA INC

Код атс:

H03AA05

ІПН (Міжнародна Ім'я):

THYROID GLAND PREPARATIONS

Дозування:

30MG

Фармацевтична форма:

TABLET

Склад:

THYROID 30MG

Адміністрація маршрут:

ORAL

Одиниць в упаковці:

100/500

Тип рецепту:

Prescription

Терапевтична области:

THYROID AGENTS

Огляд продуктів:

Active ingredient group (AIG) number: 0107351004; AHFS:

Статус Авторизація:

APPROVED

Дата Авторизація:

2022-10-04

Характеристики продукта





PRESCRIBING INFORMATION
Pr
THYROID
Desiccated Thyroid
Thyroid Tablets, C.S.D.
30, 60, 125 mg
Hypothyroidism Therapy
Searchlight Pharma Inc.
1600 Notre-Dame West, suite 312
Montreal, QC
H3J 1M1
Date of Preparation: OCT 4, 2022
Submission Control No: 267094




PRESCRIBING INFORMATION
PR THYROID
DESICCATED THYROID
THYROID TABLETS, C.S.D.
30, 60 AND 125 MG
THERAPEUTIC CLASSIFICATION
HYPOTHYROIDISM THERAPY
ACTIONS AND CLINICAL PHARMACOLOGY
The principal pharmacologic effect of exogenous thyroid hormones is to
increase the metabolic
rate of body tissues.
The normal thyroid gland contains approximately 200 µg of
levothyroxine (T4)/g of gland, and 15
µg of triiodothyronine (T3)/g. The ratio of these two hormones in the
circulation does not
represent the ratio in the thyroid gland, since about 80% of
peripheral triiodothyronine comes
from monodeiodination of the outer ring of levothyroxine. Peripheral
monodeiodination of
levothyroxine at the 5 position (inner ring) also results in the
formation of reverse
triiodothyronine (r T3), which is calorigenically inactive. These
facts would seem to advocate
levothyroxine as the treatment of choice for the hypothyroid patient
and to mitigate against the
administration of hormone combinations which while normalizing
thyroxine levels, may produce
triiodothyronine levels in the thyrotoxic range.
Triiodothyronine (T3) level is low in the fetus and newborn, in old
age, in chronic caloric
deprivation, hepatic cirrhosis, renal failure, surgical stress, and
chronic illnesses representing
what has been called the “low triiodothyronine syndrome.”
Pharmacokinetics:
Animal studies have shown that T4 is only partially absorbed from the
gastrointestinal tract. The degree of absorption is dependent on the
vehicle used for its
administration and by the character of the intestinal contents, the
intestinal flora, including
plasma protein, soluble dietary factors, all of which bind thyroid and
thereby make it unavailable
for diffusion. Only 41% is absorbed whe