Страна: Канада
мова: англійська
Джерело: Health Canada
CLOBETASOL PROPIONATE
TEVA CANADA LIMITED
D07AD01
CLOBETASOL
0.05%
LOTION
CLOBETASOL PROPIONATE 0.05%
TOPICAL
20/60 ML
Prescription
ANTI-INFLAMMATORY AGENTS
Active ingredient group (AIG) number: 0110995001; AHFS:
APPROVED
2002-05-01
PRODUCT MONOGRAPH PR TEVA-CLOBETASOL CLOBETASOL 17-PROPIONATE 0.05% CREAM, OINTMENT AND SCALP LOTION TOPICAL ANTI-INFLAMMATORY STEROID TEVA CANADA LIMITED DATE OF PREPARATION: 30 NOVOPHARM COURT TORONTO, ONTARIO DECEMBER 18, 2017 CANADA M1B 2K9 WWW.TEVACANADA.COM CONTROL #: 211470 Page 2 PRODUCT MONOGRAPH PR TEVA-CLOBETASOL CLOBETASOL 17-PROTIONATE 0.05% CREAM, OINTMENT AND SCALP LOTION TOPICAL ANTI-INFLAMMATORY STEROID CLINICAL PHARMACOLOGY ACTIONS TEVA-CLOBETASOL (clobetasol 17-propionate 0.05%) is a highly potent topical corticosteroid. The corticosteroids are a class of compounds comprising steroid hormones that are secreted by the adrenal cortex and their synthetic analogs. In pharmacologic doses, corticosteroids are used primarily for their anti-inflammatory and/or immunosuppressive effects. Topical corticosteroids such as clobetasol are effective in the treatment of corticosteroid-responsive dermatoses primarily because of their anti-inflammatory, antipruritic, and vasoconstrictive actions. PHARMACOKINETICS: In man, the extent of percutaneous absorption of topical corticosteroids, including clobetasol, is determined by many factors, including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressing. As with all topical corticosteroids, clobetasol can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin may increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Once absorbed through the skin, topical corticosteroids enter pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids, including clobetasol and its metabolites, are also excreted in the bile. BIOAVAILABILITY The relative potency of corticosteroids is usually assayed by the vasoconstriction te Прочитайте повний документ