SULFAMETHOXAZOLE AND TRIMETHOPRIM tablet

Страна: США

мова: англійська

Джерело: NLM (National Library of Medicine)

Активний інгредієнт:

Sulfamethoxazole (UNII: JE42381TNV) (Sulfamethoxazole - UNII:JE42381TNV), Trimethoprim (UNII: AN164J8Y0X) (Trimethoprim - UNII:AN164J8Y0X)

Доступна з:

TYA Pharmaceuticals

ІПН (Міжнародна Ім'я):

Sulfamethoxazole

Склад:

Sulfamethoxazole 800 mg

Адміністрація маршрут:

ORAL

Тип рецепту:

PRESCRIPTION DRUG

Терапевтичні свідчення:

To reduce the development of drug-resistant bacteria and maintain the effectiveness of sulfamethoxazole and trimethoprim tablets and other antibacterial drugs, sulfamethoxazole and trimethoprim tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to empiric selection of therapy. For the treatment of urinary tract infections due to susceptible strains of the following organisms: species, species, and . It is recommended that initial episodes of uncomplicated urinary tract infections be treated with a single effective antibacterial agent rather than the combination. Urinary Tract Infections: Escherichia coli, Klebsiella Enterobacter Morganella morganii, Proteus mirabilis Pro

Огляд продуктів:

NDC:64725-0146-1 in a BOTTLE of 100 TABLETS Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature] DISPENSE IN TIGHT, LIGHT-RESISTANT CONTAINER.

Статус Авторизація:

Abbreviated New Drug Application

Характеристики продукта

SULFAMETHOXAZOLE AND TRIMETHOPRIM- SULFAMETHOXAZOLE AND TRIMETHOPRIM
TABLET
TYA PHARMACEUTICALS
----------
SULFAMETHOXAZOLE AND TRIMETHOPRIM TABLETS USP
RX ONLY
To reduce the development of drug-resistant bacteria and maintain the
effectiveness of
sulfamethoxazole and trimethoprim tablets and other antibacterial
drugs, sulfamethoxazole and
trimethoprim tablets should be used only to treat or prevent
infections that are proven or strongly
suspected to be caused by bacteria.
DESCRIPTION
Sulfamethoxazole and trimethoprim is a synthetic antibacterial
combination product available in DS
(double strength) tablets, each containing 800 mg sulfamethoxazole and
160 mg trimethoprim; in tablets,
each containing 400 mg sulfamethoxazole and 80 mg trimethoprim for
oral administration.
Sulfamethoxazole is -(5-methyl-3-isoxazolyl)sulfanilamide; the
molecular formula is C H N O S. It is an
almost white, odorless, tasteless compound with a molecular weight of
253.28 and the following
structural formula: _N_
Trimethoprim is 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine; the
molecular formula is C H N O .
It is a white to light yellow, odorless, bitter compound with a
molecular weight of 290.3 and the
following structural formula:
Docusate sodium 85%, sodium benzoate 15%, sodium starch glycolate,
magnesium stearate and
pregelatinized starch. INACTIVE INGREDIENTS:
1
101133
141843
CLINICAL PHARMACOLOGY
Sulfamethoxazole and trimethoprim is rapidly absorbed following oral
administration. Both
sulfamethoxazole and trimethoprim exist in the blood as unbound,
protein-bound and metabolized forms;
sulfamethoxazole also exists as the conjugated form. Sulfamethoxazole
is metabolized in humans to at
least 5 metabolites: the N -acetyl-, N -hydroxy-, 5-methylhydroxy-, N
-acetyl- 5-methylhydroxy-
sulfamethoxazole metabolites, and an N-glucuronide conjugate. The
formulation of N -hydroxy
metabolite is mediated CYP2C9.
_via_
Trimethoprim is metabolized to 11 different metabolites, of which,
five are glutathione adducts and six
are oxidative metabo