Страна: Малайзія
мова: англійська
Джерело: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
SUMATRIPTAN SUCCINATE
JETPHARMA SDN. BHD.
SUMATRIPTAN SUCCINATE
4Tablet Tablets
INTAS PHARM LTD
For the use of a Registered Medical Practitioner or a Hospital or a Laboratory only. STRIPTAN 50 & STRIPTAN 100 (SUMATRIPTAN SUCCINATE TABLETS 50 MG &100 MG) NAME OF PRODUCT STRIPTAN 50 (Sumatriptan Succinate Tablets 50 mg) STRIPTAN 100 (Sumatriptan Succinate Tablets 100 mg) NAME AND STRENGTH OF ACTIVE INGREDIENT Sumatriptan Succinate Ph. Eur. eq. to Sumatriptan 50 mg Sumatriptan Succinate Ph. Eur. eq. to Sumatriptan 100 mg DOSAGE FORM Film Coated Tablet PRODUCT DESCRIPTION SUMATRIPTAN SUCCINATE TABLETS 50 MG: Pink colored, capsule shaped biconvex, film coated tablet plain on both sides. SUMATRIPTAN SUCCINATE TABLETS 100 MG: White to off-white, capsule shaped biconvex, film coated tablet plain on both sides. PHARMACODYNAMICS & PHARMACOKINETICS PHARMACODYNAMIC PROPERTIES Pharmacotherapeutic group: Analgesics: Selective 5-HT1 receptor agonists. ATC code: N02CC01 Sumatriptan has been demonstrated to be a specific and selective 5-Hydroxy- tryptamine1 (5HT1D) receptor agonist with no effect on other 5HT receptor (5-HT2-5-HT7) subtypes. The vascular 5-HT1D receptor is found predominantly in cranial blood vessels and mediates vasoconstriction. In animals, sumatriptan selectively constricts the carotid arterial circulation but does not alter cerebral blood flow. The carotid arterial circulation supplies blood to the extracranial and intracranial tissues such as the meninges and dilatation of and/or oedema formation in these vessels is thought to be the underlying mechanism of migraine in man. In addition, evidence from animal studies suggests that sumatriptan inhibits trigeminal nerve activity. Both these actions (cranial vasoconstriction and inhibition of trigeminal nerve activity) may contribute to the anti-migraine action of sumatriptan in humans. Sumatriptan remains effective in treating menstrual migraine i.e. migraine without aura that occurs between 3 days prior and up to 5 days post onset of menstruation. Sumatriptan should be taken as soon as possible in an attack. Clinical response begins around 30 minutes foll Прочитайте повний документ