Страна: Малайзія
мова: англійська
Джерело: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
SODIUM CITRATE; DIPHENHYDRAMINE HYDROCHLORIDE; AMMONIUM CHLORIDE
DYNAPHARM MARKETING (M) SDN BHD
SODIUM CITRATE; DIPHENHYDRAMINE HYDROCHLORIDE; AMMONIUM CHLORIDE
100 ml
DYNAPHARM (M) SDN BHD
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ SINARDRYL SYRUP Diphenhydramine hydrochloride/Ammonium chloride/Sodium citrate (14mg/135mg/57mg per 5 ml) 1 WHAT IS IN THIS LEAFLET 1. What SINARDRYL SYRUP_ _is used for 2. How SINARDRYL SYRUP_ _works 3. Before you use SINARDRYL SYRUP 4. How to use SINARDRYL SYRUP 5. While you are using it 6. Side effects 7. Storage and Disposal of SINARDRYL SYRUP 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT SINARDRYL SYRUP IS USED FOR It is indicated for irritating coughs, nasal stuffiness and airway congestion associated with common cold and allergy. HOW SINARDRYL SYRUP WORKS Diphenhydramine suppresses the cough reflex by a direct effect on the cough centre in the brain. It also works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. The action of antihistamine provides a drying effect in the nose lining. It diminishes vestibular stimulation (the process of sending specific electric messages to a nerve in the ear that maintains balance) and depress labyrinthine function (hearing and balance). An action on the brain trigger zone may also be involved in the antiemetic (vomiting and nausea) effect. Ammonium Chloride has irritant action on the gastric lining and may contribute expectorant action (to loosen and clear mucus from the airways). Sodium Citrate when used together with Ammonium Chloride in oral preparation may enhance the expectorant action. BEFORE YOU USE SINARDRYL SYRUP - _When you must not use it _ This preparation should not be used in newborn or premature infants and in nursing mother. It should not be used to treat lower respiratory tract symptoms including asthma. It is also not to be used in cases of hypersensitivity to Diphenhydramine, other similar antihistamine or other ingredients listed at the end of this leaflet. Not to be used in children less than 2 years of age. To be used with caution and doctor’s / pharmacist’s advice in children 2 to 6 years of ag Прочитайте повний документ
SINARDRYL SYRUP MAL23086011ACZ DESCRIPTION: SYRUP Colour : Dark Brown Flavour : Raspberry and Plum EACH 5 ML CONTAINS: Diphenhydramine HCl ..................................................................... 14 mg Ammonium Chloride ..................................................................... 135 mg Sodium Citrate ................................................................................. 57 mg PRESERVATIVES: Sodium Benzoate 5 mg, Methyl Paraben 5 mg, Propyl Paraben 0.5 mg PHARMACODYNAMICS: Diphenhydramine suppresses the cough reflex by a direct effect on the cough centre in the medulla of the brain. Its antihistaminic action is by competing with histamine for H1-receptor sites on effector cells. The antimuscarinic actions of antihistamine provides a drying effect on the nasal mucosa. It diminishes vestibular stimulation and depress labyrinthine function. An action on the medullary chemoreceptive trigger zone may also be involved in the antiemetic effect. Ammonium Chloride has irritant action on the gastric mucous membrane and may contribute expectorant action. Sodium Citrate when used together with Ammonium Chloride in oral preparation may enhance the expectorant action. PHARMACOKINETICS: Diphenhydramine is readily absorbed from the GIT. It is metabolised in the liver and excreted mainly as metabolites in the urine. After an oral dose of 50 mg of Diphenhydramine HCl, plasma concentrations of 50 to 54 ng/ml are attained at 1 hour; at 2 hours, plasma concentration is 64 to 70 ng/ml. The plasma half-life after an oral dose is 13 to 21 hours. 98% is bound to plasma proteins. About 50% of an oral dose is metabolised in the liver before reaching the general circulation. Reactions include N-deakylation and deamination. In the urine, up to 3% of a dose is excreted unchanged, up to 13% as basic amines and up to 65% as diphenylmethane metabolites. The major urinary metabolite appears to be diphenylmethoxyacetic acid in free or conjugated form. Ammonium Chloride is rapidly absorbed from the GIT. The Ammonium Прочитайте повний документ