Страна: Сінгапур
мова: англійська
Джерело: HSA (Health Sciences Authority)
Isosorbide-5-mononitrate
ZUELLIG PHARMA PTE. LTD.
C01DA14
60 mg
TABLET, FILM COATED
Isosorbide-5-mononitrate 60 mg
ORAL
Prescription Only
AstraZeneca Pharmaceutical Co. Ltd
ACTIVE
1988-06-24
IMDUR ® 60 MG Isosorbide-5-mononitrate in a controlled release formulation (Durules ® ) DESCRIPTION Imdur ® Durules ® contain isosorbide mononitrate (AAN) in a sustained release formulation. The chemical name is 1,4:3,6-Dianhydro -D-glucitol 5-nitrate. Molecular formula C 6 H 9 NO 6 ; m.w. 191.14. Isosorbide mononitrate is a white to pale yellow crystalline powder and is freely soluble in water. CAS 16051-77-7. The chemical structure of isosorbide mononitrate is: Imdur Durules contain the active drug embedded in a porous inert matrix consisting of paraffin- synthetic, aluminium sodium silicate, magnesium stearate, hydroxypropylcellulose and silica-colloidal anhydrous. In addition the tablet coating contains hypromellose, macrogol, titanium dioxide, hydrogen peroxide, paraffin-synthetic and water-purified. PHARMACOLOGY Isosorbide mononitrate is an active metabolite of isosorbide dinitrate and exerts qualitatively similar effects. Isosorbide mononitrate reduces the workload of the heart by producing venous and arterial dilatation. By reducing the end diastolic pressure and volume, isosorbide mononitrate lowers the intramural pressure, hence leading to an improvement in the subendocardial blood flow. The net effect when administering isosorbide mononitrate is therefore a reduced workload for the heart and an improvement in the oxygen supply/ demand balance of the myocardium. Nitrates are highly effective in the prophylaxis of symptomatic and asymptomatic myocardial ischaemia. Nitrates dilate coronary arteries not only in pre- and post-stenotic vessels, but also in eccentric lesions. The natural initiator of vascular relaxation is thought to be endothelium-derived relaxing factor (EDRF), which has both the clinical and biological characteristics of nitric oxide (NO). Organic nitrates are metabolised to NO in the muscle cell via a sulfhydryl dependent mechanism. They are therefore thought to be the physiological substitute for EDRF. PHARMACOKINETICS Isosorbide mononitrate has an elimination half- life of around fi Прочитайте повний документ
IMDUR ® 60 MG Isosorbide-5-mononitrate in a controlled release formulation (Durules ® ) DESCRIPTION Imdur ® Durules ® contain isosorbide mononitrate (AAN) in a sustained release formulation. The chemical name is 1,4:3,6-Dianhydro -D-glucitol 5-nitrate. Molecular formula C 6 H 9 NO 6 ; m.w. 191.14. Isosorbide mononitrate is a white to pale yellow crystalline powder and is freely soluble in water. CAS 16051-77-7. The chemical structure of isosorbide mononitrate is: Imdur Durules contain the active drug embedded in a porous inert matrix consisting of paraffin- synthetic, aluminium sodium silicate, magnesium stearate, hydroxypropylcellulose and silica- colloidal anhydrous. In addition the tablet coating contains hypromellose, macrogol, titanium dioxide, hydrogen peroxide, paraffin- synthetic and water-purified. PHARMACOLOGY Isosorbide mononitrate is an active metabolite of isosorbide dinitrate and exerts qualitatively similar effects. Isosorbide mononitrate reduces the workload of the heart by producing venous and arterial dilatation. By reducing the end diastolic pressure and volume, isosorbide mononitrate lowers the intramural pressure, hence leading to an improvement in the subendocardial blood flow. The net effect when administering isosorbide mononitrate is therefore a reduced workload for the heart and an improvement in the oxygen supply/demand balance of the myocardium. Nitrates are highly effective in the prophylaxis of symptomatic and asymptomatic myocardial ischaemia. Nitrates dilate coronary arteries not only in pre- and post-stenotic vessels, but also in eccentric lesions. The natural initiator of vascular relaxation is thought to be endothelium- derived relaxing factor (EDRF), which has both the clinical and biological characteristics of nitric oxide (NO). Organic nitrates are metabolised to NO in the muscle cell via a sulfhydryl dependent mechanism. They are therefore thought to be the physiological substitute for EDRF. PHARMACOKINETICS Isosorbide mononitrate has an elimination half-life of around f Прочитайте повний документ