Страна: Малайзія
мова: англійська
Джерело: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
METFORMIN HYDROCHLORIDE
DYNAPHARM (M) SDN BHD
METFORMIN HYDROCHLORIDE
1000 Tablet Tablets; 100 Tablet Tablets
DYNAPHARM (M) SDN BHD
Consumer Medication Information Leaflet (RiMUP) DYNA METFORMIN TABLET 500MG Metformin Hydrochloride (500mg) Page 1 of 3 What is in this leaflet 1. What Metformin is used for 2. How Metformin works 3. Before you take Metformin 4. How to take Metformin 5. While you are using Metformin 6. Side Effects 7. Storage and disposal of Metformin 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision What METFORMIN is used for Metformin belongs to a group of medicines called biguanides (a type of oral hypoglycaemic). Metformin is used for the sort of diabetes called Type 2 diabetes or non-insulin-dependent diabetes mellitus. This medicine is given when diet and exercise alone has not been able to control your blood sugar levels. Metformin can be given on its own. However, sometimes it is given with other medicines for diabetes or with insulin. How METFORMIN works In type 2 diabetes, there is too much sugar (glucose) in your blood. This is because your body does not make enough insulin or because it makes insulin that does not work properly. Insulin is a hormone that allows your body tissue to take glucose from the blood and use it for energy or for storage for future use. Metformin works by improving the sensitivity of your body to insulin. It helps your body to use glucose in the normal way again. Before you use METFORMIN When you must not take it Do not take Metformin if: - You are allergic (hypersensitive) to Metformin or any of the other ingredients in this tablet (see section on Product description (ingredients). An allergic reaction can include a rash, itching or shortness of breath. - You have recently had a heart attack or any other heart problems - You have severe circulation problems or difficulty in breathing - You have liver or kidney problems - You have had serious problems with your diabetes in the past called diabetic ketoacidosis. When you have this you lose weight quickly, feel sick (nausea) or are sick (vomiting). See also the section on ‘side effects’. - You have re Прочитайте повний документ
DYNA METFORMIN TABLET 500MG MAL19961876AZ DESCRIPTION: TABLET Shape : Round/Flat/Scored Colour : White Marking : “M” Oral Hypoglycaemic EACH TABLET CONTAINS: Metformin HCl .................................................. 500 mg PHARMACODYNAMICS: Metformin's mode of action is not clear. It does not stimulate Insulin releases but does require some Insulin be present for it to exert a hypoglycaemic effect. Possible mechanisms of action include delay in the absorption of Glucose from the gastrointestinal tract, an increase in Insulin sensitivity, and inhibition of hepatic gluconeogenesis. PHARMACOKINETICS: Metformin Hydrochloride is absorbed from the gastrointestinal tract and is excreted, unchanged, in the urine. It has a plasma half-life of about 3 hours and it is not bound to plasma proteins. INDICATION: Control of hyperglycaemic of maturity onset diabetes mellitus. It is used in non Insulin-dependant diabetes mellitus when diet control fails. It is sometimes given to patients no longer responding to the sulphonylureas. RECOMMENDED DOSE: Initial dose of 500 mg three times daily or 850 mg twice daily with meals, gradually increased if necessary to a maximum of 3 g daily. Renal impairment: A glomerular filtration rate (GFR) should be assessed before initiation of treatment with Metformin containing products and at lease annually thereafter. In patients at an increased risk of further progression of renal impairment and in the elderly, renal function should be assessed more frequently, e.g. every 3-6 months. GFR mL/min Total maximum daily dose (to be divided into 2-3 daily doses) Additional considerations 60-89 3000 mg Dose reduction may be considered in relation to declining renal function. 45-59 2000 mg Factors that may increase the risk of lactic acidosis should be reviewed before considering initiation of Metformin. The starting dose is at most half of the maximum dose. 30-44 1000 mg <30 - Metformin is contraindicated ROUTE OF ADMINISTRATION: FOR ORAL USE ONLY CONTRAINDICATIONS: Metformin should not be used Прочитайте повний документ