DOPAMINE HCL- dopamine hcl injection, solution

Страна: США

мова: англійська

Джерело: NLM (National Library of Medicine)

Активний інгредієнт:

DOPAMINE HYDROCHLORIDE (UNII: 7L3E358N9L) (DOPAMINE - UNII:VTD58H1Z2X)

Доступна з:

Cardinal Health

ІПН (Міжнародна Ім'я):

DOPAMINE HYDROCHLORIDE

Склад:

DOPAMINE HYDROCHLORIDE 40 mg in 1 mL

Адміністрація маршрут:

INTRAVENOUS

Тип рецепту:

PRESCRIPTION DRUG

Терапевтичні свідчення:

DOPAMINE is indicated for the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarctions, trauma, endotoxic septicemia, open heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure. Where appropriate, restoration of blood volume with a suitable plasma expander or whole blood should be instituted or completed prior to administration of DOPAMINE. Patients most likely to respond adequately to DOPAMINE are those in whom physiological parameters, such as urine flow, myocardial function, and blood pressure, have not undergone profound deterioration. Multiclinic trials indicate that the shorter the time interval between onset of signs and symptoms and initiation of therapy with volume correction and DOPAMINE, the better the prognosis. Urine flow appears to be one of the better diagnostic signs by which adequacy of vital organ perfusion can be monitored. Nevertheless, the physician should also observe the patient for signs of reversal of confusio

Огляд продуктів:

Dopamine HCl Injection, USP is available as follows: NDC 0517-1805-25 200 mg/5 mL Vial (40 mg/mL) Packages of 25 vials (color-coded WHITE) NDC 0517-1905-25 400 mg/5 mL Vial (80 mg/mL) Packages of 25 vials (color-coded GREEN) NDC 0517-1305-25 800 mg/5 mL Vial (160 mg/mL) Packages of 25 vials (color-coded YELLOW) Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) (See USP Controlled Room Temperature). Avoid contact with alkalis (including sodium bicarbonate), oxidizing agents or iron salts. NOTE - Do not use the injection if it is darker than slightly yellow or discolored in any other way. WARNING: NOT FOR DIRECT INTRAVENOUS INJECTION, MUST BE DILUTED BEFORE USE. IV INFUSION ONLY. AMERICAN REGENT, INC. SHIRLEY, NY 11967 IN1805 Rev. 1/09 Cardinal Health Zanesville, OH 43701 IA61620612

Статус Авторизація:

Abbreviated New Drug Application

Характеристики продукта

DOPAMINE HCL- DOPAMINE HCL INJECTION, SOLUTION
CARDINAL HEALTH
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DOPAMINE HYDROCHLORIDE INJECTION, USP
RX ONLY
DESCRIPTION
Dopamine Hydrochloride Injection, USP is a clear, practically
colorless, aqueous, additive solution for
intravenous infusion after dilution. Each mL contains either 40 mg, 80
mg, or 160 mg dopamine HCl,
USP (equivalent to 32.3 mg, 64.6 mg and 129.2 mg dopamine base
respectively) in Water for Injection,
USP, containing 9 mg sodium metabisulfite as an antioxidant. The pH
range (2.5 to 5.0) may be adjusted
with citric acid and/or sodium citrate. The solution is sterile and
nonpyrogenic. Dopamine HCl, a
naturally occurring catecholamine, is an inotropic vasopressor agent.
Its chemical name is 3,4
dihydroxyphenethylamine hydrochloride and its chemical structure is:
Dopamine HCl is sensitive to alkalis, iron salts and oxidizing agents.
DOPAMINE must be diluted in an
appropriate, sterile parenteral solution (see DOSAGE AND
ADMINISTRATION section) before
intravenous administration.
CLINICAL PHARMACOLOGY
Dopamine is a natural catecholamine formed by the decarboxylation of
3,4-dihydroxyphenylalanine
(DOPA). It is a precursor to norepinephrine in noradrenergic nerves
and is also a neurotransmitter in
certain areas of the central nervous system, especially in the
nigrostriatal tract, and in a few peripheral
sympathetic nerves.
Dopamine produces positive chronotropic and inotropic effects on the
myocardium, resulting in
increased heart rate and cardiac contractility. This is accomplished
directly by exerting an agonist
action on beta-adrenoceptors and indirectly by causing release of
norepinephrine from storage sites in
sympathetic nerve endings.
Dopamine’s onset of action occurs within five minutes of intravenous
administration, and with
dopamine’s plasma half-life of about two minutes, the duration of
action is less than ten minutes. If
monoamine oxidase (MAO) inhibitors are present, however, the duration
may increase to one hour. The
drug is widely distributed in the body but does not cros