Страна: Австралія
мова: англійська
Джерело: Department of Health (Therapeutic Goods Administration)
Clindamycin hydrochloride
July 2011 CLINDATECH ® ACNE TREATMENT TOPICAL SOLUTION Clindamycin Hydrochloride 1% CONSUMER MEDICINE INFORMATION PLEASE READ THIS LEAFLET CAREFULLY BEFORE YOU START CLINDATECH TREATMENT, EVEN IF YOU HAVE USED CLINDATECH BEFORE. THIS LEAFLET ANSWERS SOME COMMON QUESTIONS IN RELATION TO CLINDATECH. IT DOES NOT CONTAIN ALL THE AVAILABLE INFORMATION. IF YOU HAVE ANY QUESTIONS OR CONCERNS ABOUT APPLYING THIS MEDICINE, PLEASE ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH YOUR MEDICINE. YOU MAY NEED TO READ IT AGAIN. IDENTIFICATION ClindaTech is the brand name of a skin preparation containing clindamycin hydrochloride and a moisturiser. ClindaTech Topical Solution is a clear solution packed in a bottle with an outer carton. It contains clindamycin hydrochloride 1% (active ingredient), ethanol, dioctyl malate and purified water. It is available in two pack types, i.e. 50mL and 100mL. WHAT CLINDATECH IS USED FOR Clindamycin belongs to a group of medicines called antibiotics. It is available only with a doctor’s prescription. Topical clindamycin is used on the skin to treat certain forms of acne. It works by decreasing acne lesions and / or stopping the growth of skin bacteria which cause acne. It is usually used by itself, but your doctor may prescribe one or more other medicines that are applied on the skin or taken by mouth. Your doctor may also prescribe ClindaTech for another purpose. Therefore, ask your doctor if you have any questions why ClindaTech has been prescribed for yo Прочитайте повний документ
CLINDATECH ® TOPICAL SOLUTION PRODUCT INFORMATION i. NAME OF THE DRUG Tradename: ClindaTech Topical Solution clindamycin (as hydrochloride) Non-proprietary name: clindamycin hydrochloride Chemical name: methyl 6-amino-7-chloro-6,7,8- trideoxy-N-[(2S,4R)-1-methyl-4-propylprolyl]-1- thio-L-threo- -D-galacto-octopyranoside hydrochloride Molecular formula: C18H33ClN2O5S.HCl Molecular Structure: Molecular Weight: 461.5 1.086g of clindamycin hydrochloride (anhydrous form) is approximately equivalent to 1g of clindamycin. ii. DESCRIPTION ClindaTech Topical Solution is a clear hydroalcoholic solution containing clindamycin hydrochloride 1%. Dioctyl malate, a noncomedogenic humectant, is incorporated to prevent skin dryness. iii. PHARMACOLOGY Pharmacological Action Clindamycin is a lincosamide antibiotic obtained as a semi- synthetic derivative from cultures of _Streptomyces lincolnensis_. It is active _in vitro _and _in vivo _against most aerobic gram-positive cocci and several anaerobic and micro-aerophilic gramnegative and gram-positive organisms including _Propionibacterium acnes_, a resident anaerobe found in acne-susceptible follicles. Cross-resistance has been demonstrated between clindamycin and lincomycin. Antagonism has been demonstrated between clindamycin and erythromycin. Clindamycin may be bacteriostatic or bactericidal in action, depending on the concentration of the drug attained at the site of infection and the susceptibility of the infecting organism. _In vitro _ studies showed that the minimum inhibitory concentration of clindamycin against most wild strains of _P. acnes _(46 strains at the concentration of 108/ml) ranged from 0.05 to 0.1 µg/ml or below. The antibacterial action appears to relate to its ability i Прочитайте повний документ