Страна: Австралія
мова: англійська
Джерело: Department of Health (Therapeutic Goods Administration)
Cefaclor monohydrate
Apotex Pty Ltd
Medicine Registered
CHEMMART CEFACLOR CD TABLETS _Contains the active ingredient, cefaclor (as cefaclor monohydrate)_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET READ THIS LEAFLET CAREFULLY BEFORE TAKING YOUR MEDICINE. THIS LEAFLET ANSWERS SOME COMMON QUESTIONS ABOUT CEFACLOR. IT DOES NOT CONTAIN ALL THE AVAILABLE INFORMATION. It does not take the place of talking to your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the last page. More recent information on this medicine may be available. ASK YOUR DOCTOR OR PHARMACIST: • if there is anything you do not understand in this leaflet, • if you are worried about taking your medicine, or • to obtain the most up-to-date information. All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits they expect it will have for you. Pharmaceutical companies cannot give you medical advice or an individual diagnosis. Keep this leaflet with your medicine. You may want to read it again. WHAT THIS MEDICINE IS USED FOR The name of your medicine is Chemmart Cefaclor CD. It contains the active ingredient, cefaclor (as cefaclor monohydrate). It is used to treat infections caused by bacteria in different parts of the body such as: • chest and lungs (lower respiratory tract) • nose, throat, sinuses and tonsils (upper respiratory tract) • bladder (lower urinary tract) • skin Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed it for another reason. This medicine is available only with a doctor's prescription. _HOW IT WORKS_ Cefaclor is an antibiotic which belongs to a group called cephalosporins. These are closely related to penicillins. It works by killing the bacteria causing your infection or by stopping its growth. It will not work against infections caused by viruses such as colds or the flu. There is no evidence that this medicine is addictive. This medicine is not expected to affect Прочитайте повний документ
Product Information – Australia Chemmart Cefaclor CD 375 mg Tablets Page 1 CHEMMART CEFACLOR CD TABLETS NAME OF THE MEDICINE Cefaclor monohydrate. Chemical Name: 3-chloro-7-D- (2-phenylglycinamido) -3-cephem-4-carboxylic acid monohydrate Structural Formula: H 2 N H O N H N S O Cl HO O H 2 O . H H Molecular Formula: C 15 H 14 CIN 3 O 4 S.H 2 O Molecular Weight: 385.83 CAS Registry Number: 70356-03-5 DESCRIPTION Cefaclor (monohydrate) is a white to off-white crystalline powder, slightly soluble in water, but is insoluble in alcohol and chloroform. PHARMACOLOGY PHARMACOKINETICS Cefaclor CD is well absorbed after oral administration, with peak plasma levels being reached in about 2 hours. Following a single dose of cefaclor CD 375 mg C max is approximately 3.8 mg/mL and AUC is 11.5 mg.h/mL. When taken with food the time to reach maximum plasma levels is increased to about 3 hours and Cmax increases by 20%. The effects of food on C max and T max are also seen with other modified release preparations of cefaclor. Other studies with sustained release preparations of cefaclor have shown that although it can be taken with or without food, total absorption is enhanced with food. When it was given within one hour after a meal, the bioavailability of sustained release cefaclor was greater than 90%, using cefaclor taken fasting as a reference. When taken in the fasting state, the bioavailability of sustained release cefaclor was 77% that of cefaclor. Compared to cefaclor (fasted state), mean peak plasma concentrations of sustained release cefaclor (both fed and fasted states) were delayed 40 to 90 minutes and were lower. Concomitant administration of cimetidine does not affect the rate or extent of absorption. Administratio Прочитайте повний документ