Страна: США
мова: англійська
Джерело: NLM (National Library of Medicine)
BUMETANIDE (UNII: 0Y2S3XUQ5H) (BUMETANIDE - UNII:0Y2S3XUQ5H)
NCS HealthCare of KY, LLC dba Vangard Labs
ORAL
PRESCRIPTION DRUG
Bumetanide tablets are indicated for the treatment of edema associated with congestive heart failure, hepatic and renal disease, including the nephrotic syndrome. Almost equal diuretic response occurs after oral and parenteral administration of bumetanide. Therefore, if impaired gastrointestinal absorption is suspected or oral administration is not practical, bumetanide should be given by the intramuscular or intravenous route. Successful treatment with bumetanide tablets following instances of allergic reactions to furosemide suggests a lack of cross-sensitivity. Bumetanide is contraindicated in anuria. Although bumetanide can be used to induce diuresis in renal insufficiency, any marked increase in blood urea nitrogen or creatinine, or the development of oliguria during therapy of patients with progressive renal disease, is an indication for discontinuation of treatment with bumetanide. Bumetanide is also contraindicated in patients in hepatic coma or in states of severe electrolyte depletion until the cond
Bumetanide Tablets USP are available as green, round, flat-faced, beveled edge, plain on one side and debossed with " 700" on other side, containing 0.5 mg bumetanide, USP. Bumetanide Tablets USP are available as yellow, round, flat-faced, beveled edge, plain on one side and debossed with" 701" on other side, containing 1 mg bumetanide, USP packaged in blistercards of 30 tablets (NDC 0615-8361-39). Bumetanide Tablets USP are available as peach, round, flat-faced, beveled edge, plain on one side and debossed with " 702" on other side, containing 2 mg bumetanide, USP packaged in blistercards of 30 tablets (NDC 0615-8362-39). Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required). Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Manufactured by: Centaur Pharmaceuticals Pvt. Ltd. Hinjewadi, Pune-411057, India. Manufactured for: Heritage Pharma Labs Inc. East Brunswick, NJ 08816 1.866.901.DRUG (3784) Iss. 05/19
Abbreviated New Drug Application
BUMETANIDE- BUMETANIDE TABLET NCS HEALTHCARE OF KY, LLC DBA VANGARD LABS ---------- RX ONLY WARNING Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required, and dose and dosage schedule have to be adjusted to the individual patient's needs (see DOSAGE AND ADMINISTRATION). DESCRIPTION Bumetanide Tablets USP are a loop diuretic available as 0.5 mg (green), 1 mg (yellow) and 2 mg (peach) tablets for oral administration; each tablet also contains: anhydrous lactose, corn starch, magnesium stearate, microcrystalline cellulose and talc, with the following colorants: 0.5 mg (D&C Yellow No. 10 Aluminum Lake and FD&C Blue No. 1 Aluminum Lake); 1 mg (D&C Yellow No. 10 Aluminum Lake); 2 mg (Ferric oxide red). Chemically, bumetanide, USP is 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid. It is a practically white powder. It is slightly soluble in water and soluble in alkaline solutions. It has the following structural formula: CLINICAL PHARMACOLOGY Bumetanide is a loop diuretic with a rapid onset and short duration of action. Pharmacological and clinical studies have shown that 1 mg bumetanide has a diuretic potency equivalent to approximately 40 mg furosemide. The major site of bumetanide action is the ascending limb of the loop of Henle. The mode of action has been determined through various clearance studies in both humans and experimental animals. Bumetanide inhibits sodium reabsorption in the ascending limb of the loop of Henle, as shown by marked reduction of free-water clearance (CH O) during hydration and tubular free-water reabsorption (T H O) during hydropenia. Reabsorption of chloride in the ascending limb is also blocked by bumetanide, and bumetanide is somewhat more chloruretic than natriuretic. 2 C 2 Potassium excretion is also increased by bumetanide, in a dose-related fashion. Bumetanide may have an additional action in the proximal tubule. Since phosphate reabsorption takes Прочитайте повний документ