Страна: Сінгапур
мова: англійська
Джерело: HSA (Health Sciences Authority)
MOMETASONE FUROATE
ORGANON SINGAPORE PTE. LTD.
R03BA07
200 mcg/inhalation
POWDER, METERED
MOMETASONE FUROATE 200 mcg/inhalation
RESPIRATORY (INHALATION)
Prescription Only
MSD INTERNATIONAL GMBH (SINGAPORE BRANCH)
ACTIVE
2000-02-08
S-032088-PwIH-PIPB.2 ASMANEX* TWISTHALER* Dry Powder Inhaler Brand of mometasone furoate FOR ORAL INHALATION DESCRIPTION: Each inhalation contains either 100 micrograms, 200 micrograms or 400 micrograms of mometasone furoate anhydrous. Inactive ingredients: Lactose (which contains trace amount of milk proteins). ACTIONS: Mometasone furoate is a topical glucocorticosteroid with local anti-inflammatory properties. It is likely that much of the mechanism for the anti-allergic and anti-inflammatory effects of mometasone furoate lies in its ability to inhibit the release of mediators of the inflammatory cascade. In vitro, mometasone furoate significantly inhibits the release of leukotrienes from leukocytes of allergic patients. In cell culture, mometasone furoate demonstrated high potency in inhibition of synthesis and release of IL-1, IL-5, IL-6, and TNFa; it is also a potent inhibitor of LT production and in addition it is an extremely potent inhibitor of the production of the Th2 cytokines, IL-4 and IL-5, from human CD4+ T-cells. Mometasone furoate has been shown in vitro to exhibit a binding affinity for the human glucocorticoid receptor, which is approximately 12 times that of dexamethasone, 7 times that of triamcinolone acetonide, 5 times that of budesonide, and 1.5 times that of fluticasone. Double-blind placebo-controlled trials of 12- weeks duration in patients ≥ 12 years of age have shown that treatment with ASMANEX* TWISTHALER* at delivered doses within the range of 200-800 micrograms per day resulted in improved lung function as measured by FEV1 and peak expiratory flow, improved asthma symptom control, and decreased need for inhaled beta-2 agonist. Improved lung function was observed within 24 hours of the start of treatment in some p Прочитайте повний документ
S-CCDS-MK0887-PwIH-052020 ASMANEX* TWISTHALER* Dry Powder Inhaler Brand of mometasone furoate FOR ORAL INHALATION DESCRIPTION: Each inhalation contains either 100 micrograms, 200 micrograms or 400 micrograms of mometasone furoate anhydrous. Inactive ingredients: Lactose (which contains trace amount of milk proteins). ACTIONS: Mometasone furoate is a topical glucocorticosteroid with local anti-inflammatory properties. It is likely that much of the mechanism for the anti-allergic and anti-inflammatory effects of mometasone furoate lies in its ability to inhibit the release of mediators of the inflammatory cascade. In vitro , mometasone furoate significantly inhibits the release of leukotrienes from leukocytes of allergic patients. In cell culture, mometasone furoate demonstrated high potency in inhibition of synthesis and release of IL-1, IL-5, IL-6, and TNFα; it is also a potent inhibitor of LT production and in addition it is an extremely potent inhibitor of the production of the TH 2 cytokines, IL-4 and IL-5, from human CD4+ T-cells. Mometasone furoate has been shown in vitro to exhibit a binding affinity for the human glucocorticoid receptor, which is approximately 12 times that of dexamethasone, 7 times that of triamcinolone acetonide, 5 times that of budesonide, and 1.5 times that of fluticasone. Double-blind placebo-controlled trials of 12 weeks duration in patients ≥ 12 years of age have shown that treatment with ASMANEX* TWISTHALER* at delivered doses within the range of 200-800 micrograms per day resulted in improved lung function as measured by FEV 1 and peak expiratory flow, improved asthma symptom control, and decreased need for inhaled beta 2 agonist. Improved lung function was observed within 24 hours of the start of treatment in some patients, although maximum benefit was not achieved before 1 to 2 weeks or longer. Improved lung function was maintained for the duration of treatment. A 12-week, placebo-controlled trial of 296 patients 4- to 11- years of age with asthma of at least 6 months duratio Прочитайте повний документ