Tarka

Ülke: Avustralya

Dil: İngilizce

Kaynak: Department of Health (Therapeutic Goods Administration)

Aktif bileşen:

Trandolapril; Verapamil hydrochloride

Mevcut itibaren:

Abbott Australasia Pty Ltd

Sınıf:

Medicine Registered

Bilgilendirme broşürü

TARKA
®
 2/180,
TARKA
®
 4/240

_trandolapril and verapamil hydrochloride (sustained release)_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Tarka.
It does not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Tarka against
the benefits they expect it will have
for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, TALK TO YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT TARKA IS USED FOR
Tarka lowers high blood pressure,
which doctors call hypertension.
Tarka modified-release tablets
belong to the group of blood-pressure
lowering medicines (also called
antihypertensives).
Tarka contains two different types of
medicines:
-
a calcium channel blocker
(verapamil)
-
an Angiotensin Converting
Enzyme (ACE) inhibitor
(trandolapril)
Everyone has blood pressure. This
pressure helps get your blood all
around your body.
Your blood pressure may be different
at different times of the day,
depending on how busy or worried
you are. You have hypertension (high
blood pressure) when your blood
pressure stays higher than is needed,
even when you are calm and relaxed.
There are usually no symptoms of
hypertension.
The only way of knowing that you
have hypertension is to have your
blood pressure checked on a regular
basis. You may feel fine and have no
symptoms, but if high blood pressure
is not treated, it can lead to serious
health problems. Tarka helps to
lower your blood pressure.
Your doctor may have prescribed
Tarka for another reason. Ask your
doctor if you have any questions
about why Tarka has been prescribed
for you.
Tarka is not recommended for use in
children under the age of 18, as there
have been no studies of its effects in
children.
This medicine is available only with
a doctor's prescription.
There is no evidence that Tarka is
addictive.
BEFORE

Ürün özellikleri

Tarka Tablets 
Version 06  
30 November 2009 
1 of 27 

PRODUCT INFORMATION 
TARKA
®
 2/180 AND TARKA
®
 4/240 
NAME OF THE MEDICINE 

Trandolapril/verapamil 

DESCRIPTION 

Tarka
®
  combines a slow release formulation of a calcium channel blocker, verapamil 
hydrochloride (Isoptin SR) and an immediate release formulation  of an angiotensin 
converting enzyme, trandolapril (Gopten). 

TRANDOLAPRIL  (CAS 87679-37-6)  is  a long acting,
highly lipophilic, non-peptide, angiotensin 
converting enzyme (ACE) inhibitor with a carboxyl group
but without a sulphydryl group.  The 
chemical  name is [2S-(1(R*(R*));2a,
3aa, 7ab)]-1-[2-[(1-(ethoxy-carbonyl)-3-phenylpropyl) 
amino]-1-oxopropyl] octahydro-1H-indole-2-carboxylic acid.  
Trandolapril is a colourless,
crystalline substance that is soluble in chloroform,
dichloromethane 
and methanol.  It is slightly soluble in water and
sparingly soluble in hydrochloric acid.  It has a 
molecular weight of 430.54 and the molecular formula is C
24
 H
34
 N
2
 O
5. 
 The structural formula 
of trandolapril is: 

VERAPAMIL HYDROCHLORIDE  (CAS 152-11-4) is a calcium ion
influx inhibitor (slow channel 
blocker or calcium ion antagonist).  
Verapamil hydrochloride is present as a racemic mixture
and different activities reside in the 
two enantiomers.  Verapamil hydrochloride is an almost
white, crystalline powder, practically 
free of odour, with a bitter taste.  It is soluble in water,
freely soluble in chloroform, sparingly 
soluble in alcohol and practically insoluble in ether.  
The chemical name of verapamil hydrochloride
is benzeneacetonitrile, 
α-[3-[{2-(3,4-
dimethoxyphenyl)ethyl}methylamino] propyl]-3,4-dimethoxy- α

-(1-methylethyl)  
monohydrochloride.  It has a molecular weight of 491.08 and
the molecular formula is 
C
27
H
38
N
2
0
4
 • HCl and it