SUNPROX 550 TABLET

Ülke: Malezya

Dil: İngilizce

Kaynak: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktif bileşen:

NAPROXEN SODIUM

Mevcut itibaren:

SUNWARD PHARMACEUTICAL SDN. BHD.

INN (International Adı):

NAPROXEN SODIUM

Paketteki üniteler:

1000 Tablets; 100 Tablets; 500 Tablets; 250 Tablets; 200 Tablets

Tarafından üretildi:

SUNWARD PHARMACEUTICAL SDN. BHD.

Bilgilendirme broşürü

PLEASE REFER TO COLUMN E12

Ürün özellikleri

SUNPROX / SUNPROX 550 TABLET
Each tablet contains: Sunprox Tablet
Sunprox 550 Tablet
Naproxen sodium
275mg
550mg
equivalent to Naproxen 250mg
500mg
PHARMACOLOGY
Naproxen sodium is a non-steroidal anti-inflammatory drug with
analgesic
and antipyretic activity. The exact mechanisms of action have not been
clearly established, but many of the actions appear to be associated
principally with the inhibition of prostaglandin synthesis. Naproxen
inhibits
the
synthesis
of
prostaglandins
in
body
tissues
by
inhibiting
cyclooxygenase, an enzyme that catalyzes the formation of
prostaglandin
precursors (endoperoxides) from arachidonic acid. Prostaglandins
appear
to
sensitize
pain
receptors
to
mechanical
stimulation
and
to
other
chemical mediators (e.g. bradykinin, histamine).
Naproxen
sodium
is
rapidly
and
completely
absorbed
from
the
gastrointestinal tract. After administration of naproxen sodium, peak
plasma levels of naproxen anion are attained in 1 to 2 hours, with
steady
state conditions normally achieved after 4 –5 doses. The mean
biological
half-life of the anion in humans is approximately 13 hours and at the
therapeutic levels it is greater than 99% albumin bound. Approximately
95%
of
the
dose
is
excreted
in
the
urine,
primarily
as
naproxen,
6-0-desmethylnaproxen or their conjugates. The rate of excretion has
been
found to coincide closely with the rate of drug disappearance from the
plasma.
INDICATIONS
Naproxen sodium is indicated in the relief of mild to moderate pain
and for
the treatment of primary dysmenorrhea. It is also indicated for the
treatment of rheumatoid arthritis, osteoarthritis, ankylosing
spondylitis,
tendinitis and bursitis and acute gout.
SIDE-EFFECTS / ADVERSE REACTIONS
Adverse reactions to naproxen mainly involve the GI tract.
Constipation,
heartburn, abdominal pain and nausea occur in about 3- 9% of patients
receiving
the
drug.
Less
frequently,
dyspepsia,
diarrhea,
stomatitis,
vomiting, anorexia and flatulence occur. Naproxen may reactivate
latent
peptic ulcer and may cause peptic ulcers in pat