PROPRANOLOL HYDROCHLORIDE tablet

Ülke: ABD

Dil: İngilizce

Kaynak: NLM (National Library of Medicine)

Aktif bileşen:

PROPRANOLOL HYDROCHLORIDE (UNII: F8A3652H1V) (PROPRANOLOL - UNII:9Y8NXQ24VQ)

Mevcut itibaren:

Preferred Pharmaceuticals Inc.

INN (International Adı):

PROPRANOLOL HYDROCHLORIDE

Kompozisyon:

PROPRANOLOL HYDROCHLORIDE 20 mg

Uygulama yolu:

ORAL

Reçete türü:

PRESCRIPTION DRUG

Terapötik endikasyonlar:

Propranolol hydrochloride tablets, USP are indicated in the management of hypertension. It may be used alone or used in combination with other antihypertensive agents, particularly a thiazide diuretic. Propranolol hydrochloride tablets, USP are not indicated in the management of hypertensive emergencies. Propranolol hydrochloride tablets, USP are indicated to decrease angina frequency and increase exercise tolerance in patients with angina pectoris. Propranolol hydrochloride tablets, USP are indicated to control ventricular rate in patients with atrial fibrillation and a rapid ventricular response. Propranolol hydrochloride tablets, USP are indicated to reduce cardiovascular mortality in patients who have survived the acute phase of myocardial infarction and are clinically stable. Propranolol hydrochloride tablets, USP are indicated for the prophylaxis of common migraine headache. The efficacy of propranolol in the treatment of a migraine attack that has started has not been established, and propranolol is no

Ürün özeti:

Propranolol Hydrochloride Tablets, USP, 20 mg are blue, round, flat faced, beveled edge, scored tablets, debossed “54” bisect “83” on one side and debossed “V” on the reverse side. They are available as follows: Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense in a well-closed, light-resistant container as defined in the USP. Protect from light.

Yetkilendirme durumu:

Abbreviated New Drug Application

Ürün özellikleri

PROPRANOLOL HYDROCHLORIDE- PROPRANOLOL HYDROCHLORIDE TABLET
PREFERRED PHARMACEUTICALS INC.
----------
PROPRANOLOL HYDROCHLORIDE TABLETS, USP
RX ONLY
DESCRIPTION
Propranolol hydrochloride is a synthetic beta-adrenergic receptor
blocking agent chemically described as 2-
Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-,
hydrochloride,(±)-. Its molecular and structural
formulae are:
Propranolol hydrochloride is a stable, white, crystalline solid which
is readily soluble in water and ethanol. Its
molecular weight is 295.80.
Propranolol hydrochloride is available as 10 mg, 20 mg, 40 mg, 60 mg,
and 80 mg tablets for oral
administration.
CLINICAL PHARMACOLOGY
GENERAL
Propranolol is a nonselective beta-adrenergic receptor blocking agent
possessing no other autonomic nervous
system activity. It specifically competes with beta-adrenergic
receptor agonist agents for available receptor
sites. When access to beta-receptor sites is blocked by propranolol,
the chronotropic, inotropic, and
vasodilator responses to beta-adrenergic stimulation are decreased
proportionately. At dosages greater than
required for beta blockade, propranolol also exerts a quinidine-like
or anesthetic-like membrane action, which
affects the cardiac action potential. The significance of the membrane
action in the treatment of arrhythmias is
uncertain.
MECHANISM OF ACTION
The mechanism of the antihypertensive effect of propranolol has not
been established. Factors that may
contribute to the antihypertensive action include: (1) decreased
cardiac output, (2) inhibition of renin release
by the kidneys, and (3) diminution of tonic sympathetic nerve outflow
from vasomotor centers in the brain.
Although total peripheral resistance may increase initially, it
readjusts to or below the pretreatment level with
chronic use of propranolol. Effects of propranolol on plasma volume
appear to be minor and somewhat
variable.
In angina pectoris, propranolol generally reduces the oxygen
requirement of the heart at any given level of
effort by blocking the catechola